IED ID | IndEnz0002018564 |
Enzyme Type ID | protease018564 |
Protein Name |
Actinidain Actinidin EC 3.4.22.14 allergen Act c 1 |
Gene Name | ACT1A CEY00_Acc12058 |
Organism | Actinidia chinensis var. chinensis (Chinese soft-hair kiwi) |
Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae asterids Ericales Actinidiaceae Actinidia Actinidia chinensis (Kiwi) (Yangtao) Actinidia chinensis var. chinensis (Chinese soft-hair kiwi) |
Enzyme Sequence | MGLPKSFVSMSLLFFSTLLILSLAFNAKNLTQRTNDEVKAMYESWLIKYGKSYNSLGEWERRFEIFKETLRFIDEHNADTNRSYKVGLNQFADLTDEEFRSTYLGFTSGSNKTKVSNQYEPRVGQVLPSYVDWRSAGAVVDIKSQGECGGCWAFSAIATVEGINKIVTGVLISLSEQELIDCGRTQNTRGCNVGYITDGFQFIINNGGINTEENYPYTAQDGECNVDLQNEKYVTIDTYENVPYNNEWALQTAVTYQPVSVALDAAGDAFKHYSSGIFIGPCGTAIDHAVTIVGYGTEGGIDYWIVKNSWDTTWGEEGYMRILRNVGGAGTCGIATMPSYPVKYNNQNHPKSYSSLINPPAFSMSNDGPVGVDDGQRYSA |
Enzyme Length | 380 |
Uniprot Accession Number | P00785 |
Absorption | |
Active Site | ACT_SITE 151; ACT_SITE 288; ACT_SITE 308 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=Specificity close to that of papain.; EC=3.4.22.14; |
DNA Binding | |
EC Number | 3.4.22.14 |
Enzyme Function | FUNCTION: Cysteine protease responsible for the cleavage of kiwellin into kissper and KiTH. {ECO:0000269|PubMed:18442249}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Beta strand (7); Chain (1); Disulfide bond (3); Frameshift (2); Helix (9); Propeptide (1); Sequence conflict (37); Signal peptide (1); Turn (1) |
Keywords | 3D-structure;Allergen;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
Interact With | |
Induction | |
Subcellular Location | |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000255 |
Structure 3D | X-ray crystallography (2) |
Cross Reference PDB | 1AEC; 2ACT; |
Mapped Pubmed ID | 1606141; |
Motif | |
Gene Encoded By | |
Mass | 42,098 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda | 3.4.22.14; |