Detail Information for IndEnz0002018566
IED ID IndEnz0002018566
Enzyme Type ID protease018566
Protein Name Disintegrin and metalloproteinase domain-containing protein 26A
ADAM 26A
EC 3.4.24.-
Testase-3
Gene Name Adam26a Adam26
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MFLKFCLWTMFFFSAWSPIGHAKYSSLLEVVTPLRVTVTRGNNISPGWLSYSLNIGGQRHIITMKPKKNLISRNFLLFTYSDQGDLLEQHHFVQNDCYYHGYVDEDLESPVIVNTCFGSLQGTLEINGTSYEIMPKSSTSTFEHLVYKMDSGDSESSPMRCGLSEEETAQQTKLQESNAPTLLQIPYENWWTHHRFIEYFVVLDHKQYVHRNNNITTCIQDMLQIVNGVNGYYLQIDTDVVLTTLEVWNEKNYINVELSIFKVLGDFCTWKQNMFGNRIRHDIIHLLVRQGYGLYLGLAYLADVCTPYNCGVSSVLSDVMSDMAHIVAHEMGHNFGMKHDGIGCTCGLKDCLMAPYKTNSPKFSNCSYEEMYSVVTKRSCLYDIPEALVTNLTVCGNKVVEEGEQCDCGNSESCLQDPCCSSDCVLKPGAQCAFGLCCKNCQFLKAGTVCRKEKNECDLPEWCNGTSAECPGDVYKADGIPCSGEGYCYKMECHQRDEQCRKIFGNGSRSADEICYMEMNRQGDRFGNCGNDSSTYRTCQIADVLCGQIQCENVIQLPQRRNHETVHYTHFSNITCWTMDYHFGITIDDIGAVSDGTAYAPDHICVDRKCVSKSVLVSNCSPQLYHMQGICNNKQHCHCGVTWKPPDCQKRGHGGSIDSGPPPLPLSHSKWIVYILIVLDVCIVIIIYLFSFYKLSK
Enzyme Length 697
Uniprot Accession Number Q9R158
Absorption
Active Site ACT_SITE 330; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095"
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (6); Domain (3); Glycosylation (8); Metal binding (4); Motif (1); Propeptide (1); Sequence conflict (3); Signal peptide (1); Topological domain (2); Transmembrane (1)
Keywords Developmental protein;Differentiation;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Spermatogenesis;Transmembrane;Transmembrane helix;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..22; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 12466851; 19129510; 21267068; 24194600; 26839965; 27626380; 8146185;
Motif MOTIF 159..166; /note=Cysteine switch; /evidence=ECO:0000250
Gene Encoded By
Mass 78,747
Kinetics
Metal Binding METAL 161; /note=Zinc; in inhibited form; /evidence=ECO:0000250; METAL 329; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 333; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 339; /note=Zinc; catalytic; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda