Detail Information for IndEnz0002018567
IED ID IndEnz0002018567
Enzyme Type ID protease018567
Protein Name Carboxypeptidase A5
EC 3.4.17.-
Gene Name Cpa5
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MQGTQRGGLVPGLSPLDRRTLLFCNFILAVAWGQVNFTGDQVLRVLAKNEKQLSLLRDLETQKPQKVDFWRGPARPSLPVDMRVPFSELPSVKAYLKSHGLAYSIMIKDIQVLLDEERDAMAKSRRLERSTNSFSYSSYHTLDEIYSWIDNFVAEHSNLVSKIHIGKSFENRSILVLKFSTGGPNRPAIWIDTGIHSREWITHATGIWISQKIVNAYGKDHVLKRILNTMDIFIEIVTNPDGFAFTHSMNRLWRKNKSSQPGIFCIGVDLNRNWKAGFGGNGSNKNPCSETYRGPAPESEPEVAAIVDFITGHGNFKAMISIHSYSQMVMYPYGHSLEPVPNHEELFNLAKDAVKALNKVHGIQYIFGSISTTLYSASGISVDWAYDSGIKYAFSFELRDTGQYGFLLPASQIVPTAEETWMALQTIMKHTLNHPY
Enzyme Length 436
Uniprot Accession Number Q8R4H4
Absorption
Active Site ACT_SITE 397; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:P00732
Activity Regulation
Binding Site BINDING 254; /note=Substrate; /evidence=ECO:0000250|UniProtKB:P00730; BINDING 375; /note=Substrate; /evidence=ECO:0000250|UniProtKB:P00730
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.17.-
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Binding site (2); Chain (1); Disulfide bond (1); Metal binding (3); Propeptide (1); Region (3); Signal peptide (1)
Keywords Carboxypeptidase;Cleavage on pair of basic residues;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..33; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 12466851; 21267068; 21677750; 33745502;
Motif
Gene Encoded By
Mass 49,151
Kinetics
Metal Binding METAL 196; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 199; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 323; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730
Rhea ID
Cross Reference Brenda