| IED ID | IndEnz0002018567 |
| Enzyme Type ID | protease018567 |
| Protein Name |
Carboxypeptidase A5 EC 3.4.17.- |
| Gene Name | Cpa5 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MQGTQRGGLVPGLSPLDRRTLLFCNFILAVAWGQVNFTGDQVLRVLAKNEKQLSLLRDLETQKPQKVDFWRGPARPSLPVDMRVPFSELPSVKAYLKSHGLAYSIMIKDIQVLLDEERDAMAKSRRLERSTNSFSYSSYHTLDEIYSWIDNFVAEHSNLVSKIHIGKSFENRSILVLKFSTGGPNRPAIWIDTGIHSREWITHATGIWISQKIVNAYGKDHVLKRILNTMDIFIEIVTNPDGFAFTHSMNRLWRKNKSSQPGIFCIGVDLNRNWKAGFGGNGSNKNPCSETYRGPAPESEPEVAAIVDFITGHGNFKAMISIHSYSQMVMYPYGHSLEPVPNHEELFNLAKDAVKALNKVHGIQYIFGSISTTLYSASGISVDWAYDSGIKYAFSFELRDTGQYGFLLPASQIVPTAEETWMALQTIMKHTLNHPY |
| Enzyme Length | 436 |
| Uniprot Accession Number | Q8R4H4 |
| Absorption | |
| Active Site | ACT_SITE 397; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:P00732 |
| Activity Regulation | |
| Binding Site | BINDING 254; /note=Substrate; /evidence=ECO:0000250|UniProtKB:P00730; BINDING 375; /note=Substrate; /evidence=ECO:0000250|UniProtKB:P00730 |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.17.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Binding site (2); Chain (1); Disulfide bond (1); Metal binding (3); Propeptide (1); Region (3); Signal peptide (1) |
| Keywords | Carboxypeptidase;Cleavage on pair of basic residues;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..33; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12466851; 21267068; 21677750; 33745502; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,151 |
| Kinetics | |
| Metal Binding | METAL 196; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 199; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 323; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730 |
| Rhea ID | |
| Cross Reference Brenda |