| IED ID | IndEnz0002018591 |
| Enzyme Type ID | protease018591 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 33 ADAM 33 EC 3.4.24.- |
| Gene Name | ADAM33 C20orf153 UNQ873/PRO1891 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW |
| Enzyme Length | 813 |
| Uniprot Accession Number | Q9BZ11 |
| Absorption | |
| Active Site | ACT_SITE 346; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (2); Beta strand (6); Chain (1); Compositional bias (1); Disulfide bond (7); Domain (3); Glycosylation (5); Helix (9); Metal binding (4); Motif (1); Natural variant (15); Propeptide (1); Region (2); Sequence conflict (2); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (3) |
| Keywords | 3D-structure;Alternative splicing;Asthma;Cleavage on pair of basic residues;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc;Zymogen |
| Interact With | Q9BXN2; Q9BRI3 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..29; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 1R54; 1R55; |
| Mapped Pubmed ID | 12535637; 12768445; 14564349; 14676211; 14720258; 14742294; 15144468; 15196271; 15298558; 15347848; 15387895; 15709049; 15766253; 15790980; 15805180; 15879414; 15986064; 16024651; 16387804; 16519819; 16650044; 16713569; 16784537; 16799089; 16839403; 16893396; 17061022; 17339047; 17545039; 17640346; 17702965; 17703412; 17878941; 17961406; 18410963; 18423563; 18425216; 18560587; 18617639; 18752037; 18778489; 18923449; 19146844; 19236319; 19247692; 19258923; 19265133; 19267929; 19284602; 19317339; 19326508; 19635592; 19665773; 19913121; 19940503; 19951440; 19996348; 20003279; 20156753; 20227692; 20237496; 20395963; 20491578; 20503287; 20524005; 20537279; 20628086; 20701904; 20716621; 21078624; 21179102; 21689380; 21781516; 21869474; 21930123; 22035178; 22227561; 22269827; 22349453; 22583515; 22660217; 22851202; 22871616; 22888638; 22989201; 23245479; 23257708; 23331525; 23380143; 23525950; 23612257; 23640030; 23640557; 23861802; 24035932; 24141861; 24191661; 24422987; 24562625; 24728305; 24751681; 25036518; 25068505; 25155083; 25158257; 25280544; 25313536; 25369941; 25453333; 25730038; 25739290; 25768087; 25840998; 26291893; 26500222; 26553447; 26619918; 26666372; 28056993; 28285393; 28294120; 28326636; 28346792; 28429897; 28876365; 29149777; 30160137; 30226539; 30791911; 31357020; 31423513; 31626088; 31719298; 33740392; 33982767; |
| Motif | MOTIF 131..138; /note=Cysteine switch; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 87,739 |
| Kinetics | |
| Metal Binding | METAL 133; /note=Zinc; in inhibited form; /evidence=ECO:0000250; METAL 345; /note=Zinc; catalytic; /evidence=ECO:0000269|PubMed:14659745; METAL 349; /note=Zinc; catalytic; /evidence=ECO:0000269|PubMed:14659745; METAL 355; /note=Zinc; catalytic; /evidence=ECO:0000269|PubMed:14659745 |
| Rhea ID | |
| Cross Reference Brenda |