Detail Information for IndEnz0002018601
IED ID IndEnz0002018601
Enzyme Type ID protease018601
Protein Name Disintegrin and metalloproteinase domain-containing protein 8
ADAM 8
EC 3.4.24.-
Cell surface antigen MS2
Macrophage cysteine-rich glycoprotein
CD antigen CD156a
Gene Name Adam8 Ms2
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MLGLWLLSVLWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRALPSHWGQYPESLSYALGTSGHVFTLHLRKNRDLLGSSYTETYSAANGSEVTEQLQEQDHCLYQGHVEGYEGSAASISTCAGLRGFFRVGSTVHLIEPLDADEEGQHAMYQAKHLQQKAGTCGVKDTNLNDLGPRALEIYRAQPRNWLIPRETRYVELYVVADSQEFQKLGSREAVRQRVLEVVNHVDKLYQELSFRVVLVGLEIWNKDKFYISRYANVTLENFLSWREQNLQGQHPHDNVQLITGVDFIGSTVGLAKVSALCSRHSGAVNQDHSKNSIGVASTMAHELGHNLGMSHDEDIPGCYCPEPREGGGCIMTESIGSKFPRIFSRCSKIDLESFVTKPQTGCLTNVPDVNRFVGGPVCGNLFVEHGEQCDCGTPQDCQNPCCNATTCQLVKGAECASGTCCHECKVKPAGEVCRLSKDKCDLEEFCDGRKPTCPEDAFQQNGTPCPGGYCFDGSCPTLAQQCRDLWGPGARVAADSCYTFSIPPGCNGRMYSGRINRCGALYCEGGQKPLERSFCTFSSNHGVCHALGTGSNIDTFELVLQGTKCEEGKVCMDGSCQDLRVYRSENCSAKCNNHGVCNHKRECHCHKGWAPPNCVQRLADVSDEQAASTSLPVSVVVVLVILVAAMVIVAGIVIYRKAPRQIQRRSVAPKPISGLSNPLFYTRDSSLPAKNRPPDPSETVSTNQPPRPIVKPKRPPPAPPGAVSSSPLPVPVYAPKIPNQFRPDPPTKPLPELKPKQVKPTFAPPTPPVKPGTGGTVPGATQGAGEPKVALKVPIQKR
Enzyme Length 826
Uniprot Accession Number Q05910
Absorption
Active Site ACT_SITE 330; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095"
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Possible involvement in extravasation of leukocytes.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Compositional bias (1); Disulfide bond (12); Domain (3); Glycosylation (4); Metal binding (3); Region (1); Signal peptide (1); Topological domain (2); Transmembrane (1)
Keywords Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..16; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11050116; 11341326; 12135759; 12372841; 12466851; 12777399; 1318459; 14756057; 14761956; 15087305; 15580619; 15907280; 16141072; 16154205; 16452166; 16602821; 16831910; 16967505; 16995821; 17072319; 17344430; 18287572; 18397961; 19003792; 19373511; 19397475; 19574220; 19737139; 20119708; 20194813; 20220092; 20605457; 20660068; 20683884; 20826683; 20856819; 21077325; 21205794; 21268008; 21282332; 21308776; 22447932; 23670189; 23833070; 24194600; 25511460; 25585999; 27626380; 28596294; 28863006; 28916789; 28973166; 33314720; 33469101; 34956566; 8163572; 9126482;
Motif
Gene Encoded By
Mass 90,046
Kinetics
Metal Binding METAL 329; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P78325; METAL 333; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P78325; METAL 339; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P78325
Rhea ID
Cross Reference Brenda