| IED ID | IndEnz0002018601 |
| Enzyme Type ID | protease018601 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 8 ADAM 8 EC 3.4.24.- Cell surface antigen MS2 Macrophage cysteine-rich glycoprotein CD antigen CD156a |
| Gene Name | Adam8 Ms2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MLGLWLLSVLWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRALPSHWGQYPESLSYALGTSGHVFTLHLRKNRDLLGSSYTETYSAANGSEVTEQLQEQDHCLYQGHVEGYEGSAASISTCAGLRGFFRVGSTVHLIEPLDADEEGQHAMYQAKHLQQKAGTCGVKDTNLNDLGPRALEIYRAQPRNWLIPRETRYVELYVVADSQEFQKLGSREAVRQRVLEVVNHVDKLYQELSFRVVLVGLEIWNKDKFYISRYANVTLENFLSWREQNLQGQHPHDNVQLITGVDFIGSTVGLAKVSALCSRHSGAVNQDHSKNSIGVASTMAHELGHNLGMSHDEDIPGCYCPEPREGGGCIMTESIGSKFPRIFSRCSKIDLESFVTKPQTGCLTNVPDVNRFVGGPVCGNLFVEHGEQCDCGTPQDCQNPCCNATTCQLVKGAECASGTCCHECKVKPAGEVCRLSKDKCDLEEFCDGRKPTCPEDAFQQNGTPCPGGYCFDGSCPTLAQQCRDLWGPGARVAADSCYTFSIPPGCNGRMYSGRINRCGALYCEGGQKPLERSFCTFSSNHGVCHALGTGSNIDTFELVLQGTKCEEGKVCMDGSCQDLRVYRSENCSAKCNNHGVCNHKRECHCHKGWAPPNCVQRLADVSDEQAASTSLPVSVVVVLVILVAAMVIVAGIVIYRKAPRQIQRRSVAPKPISGLSNPLFYTRDSSLPAKNRPPDPSETVSTNQPPRPIVKPKRPPPAPPGAVSSSPLPVPVYAPKIPNQFRPDPPTKPLPELKPKQVKPTFAPPTPPVKPGTGGTVPGATQGAGEPKVALKVPIQKR |
| Enzyme Length | 826 |
| Uniprot Accession Number | Q05910 |
| Absorption | |
| Active Site | ACT_SITE 330; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Possible involvement in extravasation of leukocytes. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Disulfide bond (12); Domain (3); Glycosylation (4); Metal binding (3); Region (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11050116; 11341326; 12135759; 12372841; 12466851; 12777399; 1318459; 14756057; 14761956; 15087305; 15580619; 15907280; 16141072; 16154205; 16452166; 16602821; 16831910; 16967505; 16995821; 17072319; 17344430; 18287572; 18397961; 19003792; 19373511; 19397475; 19574220; 19737139; 20119708; 20194813; 20220092; 20605457; 20660068; 20683884; 20826683; 20856819; 21077325; 21205794; 21268008; 21282332; 21308776; 22447932; 23670189; 23833070; 24194600; 25511460; 25585999; 27626380; 28596294; 28863006; 28916789; 28973166; 33314720; 33469101; 34956566; 8163572; 9126482; |
| Motif | |
| Gene Encoded By | |
| Mass | 90,046 |
| Kinetics | |
| Metal Binding | METAL 329; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P78325; METAL 333; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P78325; METAL 339; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P78325 |
| Rhea ID | |
| Cross Reference Brenda |