Detail Information for IndEnz0002018606
IED ID IndEnz0002018606
Enzyme Type ID protease018606
Protein Name Gamma-adducin
Adducin-like protein 70
Gene Name Add3 Addl
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MSSDTSPAVVTTPPPPSMPHKERYFDRINESDPEYLRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPSGLLALQQIADYIVTSSFSGFSSPSLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLADLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASTLVKVNIIGEVVDQGSTDLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLILGDVAYYDYQGSLDEEEERIELQKVLGPSCKVLVLRNHGMVALGETLEEAFHYIFNVQMACEIQVQAVAGAGGVDNLLVLDLQKYKAFTHGVAMSGGGGVNMASHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLVREKPRHKSDVEIPATVTAFSFEDDSAPLSPLKFMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDSSKVSSGTPIKIEDPNQFVPLNTNPTEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFDDDDQGPPAPPNPFSHLLEGELEEYTKTIERKQQGLDDAEQGSLSDDAASVSQIQSQTQSPQSVPERLEENHELFSKSFTSMDAPVMIMNGKDEMHDVEDELAQRVSRLTTSTTIENIEITIKSPERTEEVLSPDGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA
Enzyme Length 706
Uniprot Accession Number Q9QYB5
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin. {ECO:0000250|UniProtKB:Q9UEY8}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (1); Chain (1); Compositional bias (2); Cross-link (1); Initiator methionine (1); Modified residue (17); Region (6); Sequence conflict (3)
Keywords Acetylation;Actin-binding;Alternative splicing;Calmodulin-binding;Cell membrane;Cytoplasm;Cytoskeleton;Isopeptide bond;Membrane;Phosphoprotein;Reference proteome;Ubl conjugation
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Modified Residue MOD_RES 2; /note="N-acetylserine"; /evidence="ECO:0000250|UniProtKB:Q9UEY8"; MOD_RES 31; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 42; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 64; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 402; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 414; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 423; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 442; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:Q9UEY8"; MOD_RES 461; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:Q9UEY8"; MOD_RES 583; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 585; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 590; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 673; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 677; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079"; MOD_RES 679; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 681; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079"; MOD_RES 683; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"
Post Translational Modification PTM: Sumoylated. {ECO:0000250}.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10485892; 11217851; 12466851; 14516684; 14610273; 16615898; 16635246; 17114649; 1864459; 18723693; 18799693; 19425068; 19900187; 21267068; 21677750; 22114352; 22357600; 22706708; 29555813;
Motif
Gene Encoded By
Mass 78,777
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda