| IED ID | IndEnz0002018612 |
| Enzyme Type ID | protease018612 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein B ADAM B EC 3.4.24.- |
| Gene Name | ADM-B AFUA_4G11150 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MRFLKSALPFVASALSLLSVQAAARSQEPSAIQHVSILEHAVINTPSHEVDHLTDFDVTFELPDKHQTIKLELEPNHDILADDAYVQYLDAEGNVHREEPIQRHEHKVFKGRSLLRRDNGLWRPVGWARVYVQRDGSKPLFEGVFSIDNDNHHVELKSTYLQKKRVEDASIPDRKDEYMVVYRDSDMIRQVRSELKRSLISSSSCQAEKLGFNSDPQHPIFRSEFQDMDLGMSSYGSMSLNSLFGLSKRQSDIGGVSGNAGGVNLAQTIGSTSGCPKTKQVALVGIAADCSFRASFDNDDAAKQWIINMVNSASDVYEKSFNISIGLRNLTMTDKTCPETAPASTQWNMPCDQSNITQRLNLFSQWRGQQSDDNAYWTLMSNCPTGSEVGLAWLGQLCNTEVTGDGSNSVSGTNVVVRVSGGGWQVFAHESGHTFGAVHDCDSMTCAQNLEASSQCCPYNRGTCDANGKYIMNPSTGADITAFSPCTIGNICSALGRNSVKSSCLSDNRNVVTYTGSQCGNGIVEAGEDCDCGGESSCGDNPCCDAKTCKFKSGAVCDDANDSCCSQCQFSPAGTVCRASLGECDLQETCTGNSSTCPADSFKKDGEKCGDTSGLTCASGQCTSRDYQCRTVMGSLIHDNNTYACPQFDSSCELICTSPSLGSCFSINQNFLDGTPCGSGGYCHNGRCDGSNFGSWVEQHKNLVIGVACGVGGLLVLSILWCMINRCRRARTVVKRPPMRPWPGPMPPPPPQMGQWAGPNRGYQGLRAEPPPPYPGPYQSATRYA |
| Enzyme Length | 785 |
| Uniprot Accession Number | Q4WQ08 |
| Absorption | |
| Active Site | ACT_SITE 430; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Probable zinc protease. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Disulfide bond (3); Domain (2); Erroneous gene model prediction (1); Glycosylation (6); Metal binding (3); Region (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..26; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 85,082 |
| Kinetics | |
| Metal Binding | METAL 429; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 433; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 439; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Rhea ID | |
| Cross Reference Brenda |