Detail Information for IndEnz0002018613
IED ID IndEnz0002018613
Enzyme Type ID protease018613
Protein Name Disintegrin and metalloproteinase domain-containing protein B
ADAM B
EC 3.4.24.-
Gene Name ADM-B TRV_04965
Organism Trichophyton verrucosum (strain HKI 0517)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Trichophyton verrucosum (Cattle ringworm fungus) Trichophyton verrucosum (strain HKI 0517)
Enzyme Sequence MKAFSCLLAVIATAASLFQHVDASHARDKLNNISRVERPVIHTPSRRVHAHSHFDLTFDLYPRRNRIKLQLEPNHDVLSHNARVTFLDTEGNVDRIERIERRDHSVFKGWAWTQAKSGVWERVGWARIIMHRDGEDPLFEGVFTVMHDHHQVIAKSKYVRKRHQQDPPLDNTPGEYMLLFRGSDIAQTQSTGNVERSIMSSPSCDADTLAYDSNSNFMFPPLPEENNTSIWNYFMTSIGKRQMTDTGGVVPGSRDLKETIGSTSGCPNTRKVALIGVVADCTYTNTFASEMDARADIISVVNAASVVYEHSFNISLTLGEINILPKNCPATASSATPFNQQCDDRAGGGSFTLADRLNTFSAWRGKKTDDFAFWTLMTDCTTENQVGLAWAAQLCVKGVQGNPDSRNSSSQAVAGANVVSKTDNTWQVFAHEAGHIFGAVHDCDSMLCQNPANPDNSRCCPATASTCDARGRFMMNPTSGSQITNFSPCSIGQICSRMARRTILTNCLTTNRGVDTISGQQCGNGIVEDGEDCDCGDEESCKGNTCCDPKTCKYTSGSQCDDANEECCKGCKFASSSTICRTSSGPCDPEEKCSGNSGDCPHDIHSKDGGTCGTDLQCASGQCTSRDLQCQMHLGNQVAGSRTVAFDSYGCEVACKDPDRPNVRYEGSLTFLDGTPCGGGGTCKNGQCSGSTFGNEVSDWVSRHKPIVIGVAVGAGCLLLLAIASCICGRSRRQRPRNRKMPPINMRPMAPAYNGWNGAPPNAQQSSPGGHPPYNNIPPPINAPPPAYPGHMPPTRYA
Enzyme Length 798
Uniprot Accession Number D4DCV9
Absorption
Active Site ACT_SITE 432; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Probable zinc protease. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Compositional bias (1); Disulfide bond (3); Domain (2); Erroneous gene model prediction (1); Glycosylation (5); Metal binding (3); Region (1); Signal peptide (1); Topological domain (2); Transmembrane (1)
Keywords Disulfide bond;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Signal;Transmembrane;Transmembrane helix;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..23; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 86,572
Kinetics
Metal Binding METAL 431; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 435; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 441; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276
Rhea ID
Cross Reference Brenda