| IED ID | IndEnz0002018619 |
| Enzyme Type ID | protease018619 |
| Protein Name |
Calpain 11 EC 3.4.22.- Calcium-activated neutral proteinase 11 CANP 11 |
| Gene Name | Capn11 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MLNFSDISYAERGMVATINSNRLKDKGVGQYQNAYNYKNQNFEDLRASCLKMGELFEDPFFPAEPQSIGFKELGPKSQEVHNVYWQRPKDIIHNPQFITNDFSPTDICQGILGDCWLLAAIGSLTTSPKLLFRVVPRSQSFKKNYAGIFHFQLWQFGHWLNVVVDDRLPTKNNKLVFVHASHRQEFWGALLEKAYAKLNGSYEALTGGSTMEGLEDFTGGMAQCIRLQNPPHNLLRLLRKALEKSSLMGCSIEVTNSDDVEKMAHNMLVKGHAYAITGLQDVYYRDKLETLIRIQNPWGRIEWNGAWSDKAKEWEEVMPEVQMQLLHKKEDGEFWMSYEDFMSNFTLLEICNLTPDALSSWDYKSCWHTTFFEGSWRRGSTAGGCRNYPETFWSNPQFRISLPETDDPEDSSDKSEMVCTCLVALMQKNWRHAREGPQLLTIGFVVFSVWYVQFQNLQDIHLKKDFFMKYRDHGFSEIFTNTREVNSHLRLPPGEYVIIPSTFEPHKDADFLLRVFTEKHSETWLLDEVNMLEQLQEETITDADLDQNSVELFETLANRDSQVDMYDLQKLLNKMSSKVKSFKSKGFSLDVCRRMVNLMDKDDSGKLGLHEFHILWKKIKKWMEIFKECDQDRSGNLNSYEMRLAIEKAGIRMNNRVTEVVVARYADANMIVDFDNFINCFLRLKAMFAFFLSMDTKKTGSICLNINQWLHITMWG |
| Enzyme Length | 716 |
| Uniprot Accession Number | Q4V8Q1 |
| Absorption | |
| Active Site | ACT_SITE 115; /evidence=ECO:0000255; ACT_SITE 272; /evidence=ECO:0000255; ACT_SITE 296; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. {ECO:0000250|UniProtKB:Q9UMQ6}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (1); Domain (3); Metal binding (10); Region (3); Sequence conflict (3) |
| Keywords | Alternative splicing;Calcium;Cytoplasmic vesicle;Hydrolase;Metal-binding;Protease;Reference proteome;Repeat;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q6J756}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 83,241 |
| Kinetics | |
| Metal Binding | METAL 600; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 602; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 604; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 606; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 611; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 630; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 632; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 634; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 636; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 641; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448 |
| Rhea ID | |
| Cross Reference Brenda |