Detail Information for IndEnz0002018619
IED ID IndEnz0002018619
Enzyme Type ID protease018619
Protein Name Calpain 11
EC 3.4.22.-
Calcium-activated neutral proteinase 11
CANP 11
Gene Name Capn11
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MLNFSDISYAERGMVATINSNRLKDKGVGQYQNAYNYKNQNFEDLRASCLKMGELFEDPFFPAEPQSIGFKELGPKSQEVHNVYWQRPKDIIHNPQFITNDFSPTDICQGILGDCWLLAAIGSLTTSPKLLFRVVPRSQSFKKNYAGIFHFQLWQFGHWLNVVVDDRLPTKNNKLVFVHASHRQEFWGALLEKAYAKLNGSYEALTGGSTMEGLEDFTGGMAQCIRLQNPPHNLLRLLRKALEKSSLMGCSIEVTNSDDVEKMAHNMLVKGHAYAITGLQDVYYRDKLETLIRIQNPWGRIEWNGAWSDKAKEWEEVMPEVQMQLLHKKEDGEFWMSYEDFMSNFTLLEICNLTPDALSSWDYKSCWHTTFFEGSWRRGSTAGGCRNYPETFWSNPQFRISLPETDDPEDSSDKSEMVCTCLVALMQKNWRHAREGPQLLTIGFVVFSVWYVQFQNLQDIHLKKDFFMKYRDHGFSEIFTNTREVNSHLRLPPGEYVIIPSTFEPHKDADFLLRVFTEKHSETWLLDEVNMLEQLQEETITDADLDQNSVELFETLANRDSQVDMYDLQKLLNKMSSKVKSFKSKGFSLDVCRRMVNLMDKDDSGKLGLHEFHILWKKIKKWMEIFKECDQDRSGNLNSYEMRLAIEKAGIRMNNRVTEVVVARYADANMIVDFDNFINCFLRLKAMFAFFLSMDTKKTGSICLNINQWLHITMWG
Enzyme Length 716
Uniprot Accession Number Q4V8Q1
Absorption
Active Site ACT_SITE 115; /evidence=ECO:0000255; ACT_SITE 272; /evidence=ECO:0000255; ACT_SITE 296; /evidence=ECO:0000255
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.22.-
Enzyme Function FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. {ECO:0000250|UniProtKB:Q9UMQ6}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Alternative sequence (1); Chain (1); Domain (3); Metal binding (10); Region (3); Sequence conflict (3)
Keywords Alternative splicing;Calcium;Cytoplasmic vesicle;Hydrolase;Metal-binding;Protease;Reference proteome;Repeat;Thiol protease
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q6J756}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 83,241
Kinetics
Metal Binding METAL 600; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 602; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 604; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 606; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 611; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 630; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 632; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 634; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 636; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 641; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448
Rhea ID
Cross Reference Brenda