Detail Information for IndEnz0002018635
IED ID IndEnz0002018635
Enzyme Type ID protease018635
Protein Name Cystatin-C
Cystatin-3
Gene Name Cst3
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MASPLRSLMLLLAVLAVAWAGTSRPPPRLLGAPQEADASEEGVQRALDFAVSEYNKGSNDAYHSRAIQVVRARKQLVAGINYYLDVEMGRTTCTKSQTNLTNCPFHDQPHLMRKALCSFQIYSVPWKGTHTLTKSSCKNA
Enzyme Length 140
Uniprot Accession Number P14841
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (2); Glycosylation (1); Motif (1); Sequence conflict (1); Signal peptide (1); Site (1)
Keywords Direct protein sequencing;Disulfide bond;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Signal;Thiol protease inhibitor
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10075146; 10930551; 10950881; 11144350; 11246163; 11431459; 12044447; 14738488; 14745560; 15197734; 1540157; 15872057; 16140167; 16248890; 16309830; 16414118; 16521186; 16935259; 17027151; 17241700; 17440810; 17462596; 18635848; 18723004; 18946178; 20352108; 20489058; 21551085; 22360852; 2471663; 2622871; 26715107; 2757396; 28053285; 29755460; 30052474; 31801142; 33030263; 7747285; 8245434; 8286570; 8590041; 8738161; 8761177; 9147287; 9222450; 9432134;
Motif MOTIF 75..79; /note=Secondary area of contact
Gene Encoded By
Mass 15,437
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda