IED ID | IndEnz0002018650 |
Enzyme Type ID | protease018650 |
Protein Name |
ATP-dependent zinc metalloprotease FTSH 10, mitochondrial AtFTSH10 EC 3.4.24.- |
Gene Name | FTSH10 At1g07510 F22G5.10 F22G5_9 |
Organism | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
Enzyme Sequence | MIFSKLGSSLARSSRSKGFVYGGGVRSAVFNQGRLRAPQNLEAAVNQVDGGLGFLRRHFASFAARKGLEAGDLSRAFANPRLRRFFSSQTPKKKNYENYYPKDSKKAPKNEQKSESRDGSKKNENENAGDAFSNEYQNMLIPLMAIALILSTFSLGSREQQQISFQEFKNKLLEAGLVDHIDVSNKEVAKVYVRSSPKSQTTEEVVQGPGNGVPAKGRGGQYKYYFNIGSVESFEEKLEEAQEAIGVNSHDFVPVTYVSETIWYQELLRFAPTLLLVATLIFGARRMQGGLGGLGGPGGKAGRGIFNIGKAQITRADKNSKNKIYFKDVAGCEEAKQEIMEFVHFLQNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESAVPFLSISGSDFMEMFVGVGPSRVRNLFQEARQCAPSIIFIDEIDAIGRARGRGGFSGGNDERESTLNQLLVEMDGFGTTAGVVVLAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFQIYLKKIKLDHEPSYYSQRLAALTPGFAGADIANVCNEAALIAARHEGATVTMAHFDSAIDRVIGGLEKKNRVISKLERRTVAYHESGHAVAGWFLEHAEPLLKVTIVPRGTAALGFAQYVPNENLLMTKEQLFDMTCMTLGGRAAEQVLIGRISTGAQNDLEKVTKMTYAQVAVYGFSDKIGLLSFPQREDEFSKPYSNRTGAMIDEEVREWVGKAYKRTVELIEEHKEQVAQIAELLLEKEVLHQDDLTKVLGERPFKSGETTNYDRFKSGFEESEKESQKESVPVKPVEDDGIPPLEPQVVPT |
Enzyme Length | 813 |
Uniprot Accession Number | Q8VZI8 |
Absorption | |
Active Site | ACT_SITE 593; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.24.- |
Enzyme Function | FUNCTION: Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system. {ECO:0000269|Ref.9}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | NP_BIND 367..374; /note=ATP; /evidence=ECO:0000255 |
Features | Active site (1); Chain (1); Compositional bias (2); Erroneous gene model prediction (1); Metal binding (3); Nucleotide binding (1); Region (2); Sequence conflict (2); Transit peptide (1); Transmembrane (1) |
Keywords | ATP-binding;Hydrolase;Membrane;Metal-binding;Metalloprotease;Mitochondrion;Mitochondrion inner membrane;Nucleotide-binding;Protease;Reference proteome;Transit peptide;Transmembrane;Transmembrane helix;Zinc |
Interact With | |
Induction | INDUCTION: By high light. {ECO:0000269|PubMed:15266057}. |
Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:14671022, ECO:0000269|Ref.9}; Single-pass membrane protein {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:14671022, ECO:0000269|Ref.9}; Matrix side {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:14671022, ECO:0000269|Ref.9}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 12185496; 14730085; 15322131; 16618929; 16829591; 17181860; 18650403; 18775970; 18805951; 20172857; 20193658; 21438879; 22121866; 29462458; |
Motif | |
Gene Encoded By | |
Mass | 89,555 |
Kinetics | |
Metal Binding | METAL 592; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 596; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 668; /note=Zinc; catalytic; /evidence=ECO:0000250 |
Rhea ID | |
Cross Reference Brenda | 3.4.24.B20; |