Detail Information for IndEnz0002018652
IED ID IndEnz0002018652
Enzyme Type ID protease018652
Protein Name ATP-dependent zinc metalloprotease FTSH 11, chloroplastic/mitochondrial
AtFTSH11
EC 3.4.24.-
Gene Name FTSH11 At5g53170 MFH8.11
Organism Arabidopsis thaliana (Mouse-ear cress)
Taxonomic Lineage cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress)
Enzyme Sequence MSSSTLQASLFLRPPLHTSSFKLYPCLFSSSSLSFCPQSLSSFYRLSSVLHNSRFRPLPCSLRQDNVASDSDFIPKDSAFEVTDSAESNRLVSDTEVSELETNDRFVGGEETKSGGEEAEVSNGVTEGKEEDQKKSKFRIVVLMMALWAAIKRAIEKVMEWEWLSWWPFSRQEKRLEKLIAEADANPKDAALQGALLAELNKHIPEAVVQRFEQREHTVDSRGVAEYIRALVITNAISEYLPDEQTGKPSSLPALLQELKHRASGNMDESFVNPGISEKQPLHVTMVNPKVSNKSRFAQELVSTILFTVAVGLVWIMGAAALQKYIGSLGGIGTSGVGSSSSYSPKELNKEITPEKNVKTFKDVKGCDDAKQELEEVVEYLKNPSKFTRLGGKLPKGILLTGAPGTGKTLLAKAIAGEAGVPFFYRAGSEFEEMFVGVGARRVRSLFQAAKKKAPCIIFIDEIDAVGSTRKQWEGHTKKTLHQLLVEMDGFEQNEGIIVMAATNLPDILDPALTRPGRFDRHIVVPSPDVRGREEILELYLQGKPMSEDVDVKAIARGTPGFNGADLANLVNIAAIKAAVEGAEKLSSEQLEFAKDRIVMGTERKTMFVSEDSKKLTAYHESGHAIVALNTKGAHPIHKATIMPRGSALGMVTQLPSNDETSVSKRQLLARLDVCMGGRVAEELIFGLDHITTGASSDLSQATELAQYMVSSCGMSEAIGPVHIKERPSSDMQSRIDAEVVKLLREAYERVKSLLKRHEKQLHTLANALLEYETLTAEDIKRILLPKQEGEKFEEQQQEEGDLVLA
Enzyme Length 806
Uniprot Accession Number Q9FGM0
Absorption
Active Site ACT_SITE 621; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V. Involved in thermotolerance but not in high light stress resistance or in the assembly/stability of the complexes I and V of the mitochondrial oxidative phosphorylation system. {ECO:0000269|PubMed:16157880, ECO:0000269|PubMed:16972866, ECO:0000269|Ref.11}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding NP_BIND 402..409; /note=ATP; /evidence=ECO:0000255
Features Active site (1); Chain (1); Metal binding (3); Mutagenesis (1); Nucleotide binding (1); Region (1); Transit peptide (1); Transmembrane (1)
Keywords ATP-binding;Chloroplast;Hydrolase;Membrane;Metal-binding;Metalloprotease;Mitochondrion;Mitochondrion inner membrane;Nucleotide-binding;Plastid;Protease;Reference proteome;Thylakoid;Transit peptide;Transmembrane;Transmembrane helix;Zinc
Interact With
Induction INDUCTION: By high light. {ECO:0000269|PubMed:15266057}.
Subcellular Location SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. Plastid, chloroplast thylakoid membrane; Single-pass membrane protein; Stromal side.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 12185496; 14576160; 17181860; 18431481; 21438879; 22121866; 22487254; 26909098; 27479913; 29320985; 31024594;
Motif
Gene Encoded By
Mass 88,717
Kinetics
Metal Binding METAL 620; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 624; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 698; /note=Zinc; catalytic; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda 3.4.24.B20;