IED ID | IndEnz0002018653 |
Enzyme Type ID | protease018653 |
Protein Name |
Gag polyprotein Core polyprotein Cleaved into: Matrix protein p10; Phosphorylated protein pp24; p12; Capsid protein p27; Nucleocapsid protein p14; p4 |
Gene Name | gag |
Organism | Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV) |
Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Orthoretrovirinae Betaretrovirus Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV) |
Enzyme Sequence | MGHTHSRQLFVHMLSVMLKHRGITVSKTKLINFLSFIEEVCPWFPREGTVNLETWKKVGEQIRTHYTLHGPEKVPVETLSFWTLIRDCLDFDNDELKRLGNLLKQEEDPLHTPDSVPSYDPPPPPPPSLKMHPSDNDDSLSSTDEAELDEEAAKYHQEDWGFLAQEKGALTSKDELVECFKNLTIALQNAGIQLPSNNNTFPSAPPFPPAYTPTVMAGLDPPPGFPPPSKHMSPLQKALRQAQRLGEVVSDFSLAFPVFENNNQRYYESLPFKQLKELKIACSQYGPTAPFTIAMIESLGTQALPPNDWKQTARACLSGGDYLLWKSEFFEQCARIADVNRQQGIQTSYEMLIGEGPYQATDTQLNFLPGAYAQISNAARQAWKKLPSSSTKTEDLSKVRQGPDEPYQDFVARLLDTIGKIMSDEKAGMVLAKQLAFENANSACQAALRPYRKKGDLSDFIRICADIGPSYMQGIAMAAALQGKSIKEVLFQQQARNKKGLQKSGNSGCFVCGQPGHRAAVCPQKHQTSVNTPNLCPRCKKGKHWARDCRSKTDVQGNPLPPVSGNWVRGQPLAPKQCYGATLQVPKEPLQTSVEPQEAARDWTSVPPPIQY |
Enzyme Length | 612 |
Uniprot Accession Number | P31622 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: [Matrix protein p10]: Matrix protein. {ECO:0000305}.; FUNCTION: [Nucleocapsid protein p14]: Nucleocapsid protein. {ECO:0000305}.; FUNCTION: [Capsid protein p27]: Capsid protein. {ECO:0000250|UniProtKB:P07567}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Beta strand (3); Chain (7); Compositional bias (1); Helix (8); Initiator methionine (1); Lipidation (1); Motif (3); Natural variant (10); Region (2); Site (6); Zinc finger (2) |
Keywords | 3D-structure;Capsid protein;Coiled coil;Host-virus interaction;Lipoprotein;Metal-binding;Myristate;Phosphoprotein;Repeat;Ribosomal frameshifting;Viral budding;Viral budding via the host ESCRT complexes;Viral matrix protein;Viral nucleoprotein;Viral release from host cell;Virion;Zinc;Zinc-finger |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: [Matrix protein p10]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Capsid protein p27]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p14]: Virion {ECO:0000305}. |
Modified Residue | |
Post Translational Modification | PTM: [Gag polyprotein]: Myristoylated. Myristoylation of the matrix (MA) domain mediates the transport and binding of Gag polyproteins to the host plasma membrane and is required for the assembly of viral particles. {ECO:0000250|UniProtKB:P10258}.; PTM: [Gag polyprotein]: Specific enzymatic cleavages in vivo yield mature proteins. {ECO:0000250|UniProtKB:P07567}. |
Signal Peptide | |
Structure 3D | X-ray crystallography (1) |
Cross Reference PDB | 2V4X; |
Mapped Pubmed ID | - |
Motif | MOTIF 202..205; /note=PTAP/PSAP motif; /evidence=ECO:0000305; MOTIF 208..211; /note=PPXY motif; /evidence=ECO:0000305; MOTIF 287..290; /note=PTAP/PSAP motif; /evidence=ECO:0000250|UniProtKB:P10258 |
Gene Encoded By | |
Mass | 68,089 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |