Detail Information for IndEnz0002018662
IED ID IndEnz0002018662
Enzyme Type ID protease018662
Protein Name ATP-dependent zinc metalloprotease FtsH
EC 3.4.24.-
Gene Name ftsH aq_936
Organism Aquifex aeolicus (strain VF5)
Taxonomic Lineage cellular organisms Bacteria Aquificae Aquificae Aquificales Aquificaceae Aquifex Aquifex aeolicus Aquifex aeolicus (strain VF5)
Enzyme Sequence MNALKNFFIWAIIIGAAIVAFNLFEGKREFTTKVSLNEVVKLVEEGKVSYAEVRGNTAIIQTKDGQKLEVTLPPNTNLVDKMVEKGVRVEVANPEPPGGWLVNVFLSWLPILFFIGIWIFLLRQMSGGGNVNRAFNFGKSRAKVYIEEKPKVTFKDVAGIEEVKEEVKEIIEYLKDPVKFQKLGGRPPKGVLLYGEPGVGKTLLAKAIAGEAHVPFISVSGSDFVEMFVGVGAARVRDLFETAKKHAPCIIFIDEIDAVGRARGAIPVGGGHDEREQTLNQLLVEMDGFDTSDGIIVIAATNRPDILDPALLRPGRFDRQIFIPKPDVRGRYEILKVHARNKKLAKDVDLEFVARATPGFTGADLENLLNEAALLAARKGKEEITMEEIEEALDRITMGLERKGMTISPKEKEKIAIHEAGHALMGLVSDDDDKVHKISIIPRGMALGVTQQLPIEDKHIYDKKDLYNKILVLLGGRAAEEVFFGKDGITTGAENDLQRATDLAYRMVSMWGMSDKVGPIAIRRVANPFLGGMTTAVDTSPDLLREIDEEVKRIITEQYEKAKAIVEEYKEPLKAVVKKLLEKETITCEEFVEVFKLYGIELKDKCKKEELFDKDRKSEENKELKSEEVKEEVV
Enzyme Length 634
Uniprot Accession Number O67077
Absorption
Active Site ACT_SITE 419; /evidence=ECO:0000255|HAMAP-Rule:MF_01458
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. {ECO:0000255|HAMAP-Rule:MF_01458}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding NP_BIND 195..202; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_01458
Features Active site (1); Beta strand (13); Chain (1); Helix (22); Metal binding (3); Nucleotide binding (1); Region (1); Topological domain (3); Transmembrane (2); Turn (2)
Keywords 3D-structure;ATP-binding;Cell inner membrane;Cell membrane;Hydrolase;Membrane;Metal-binding;Metalloprotease;Nucleotide-binding;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (5)
Cross Reference PDB 2DI4; 4WW0; 4Z8X; 6GCN; 6GCO;
Mapped Pubmed ID 12377127; 26057670; 30118817;
Motif
Gene Encoded By
Mass 70,686
Kinetics
Metal Binding METAL 418; /note=Zinc; catalytic; /evidence=ECO:0000305; METAL 422; /note=Zinc; catalytic; /evidence=ECO:0000305; METAL 496; /note=Zinc; catalytic; /evidence=ECO:0000305
Rhea ID
Cross Reference Brenda 3.4.24.B17;3.4.24.B20;