Detail Information for IndEnz0002018668
IED ID IndEnz0002018668
Enzyme Type ID protease018668
Protein Name ATP-dependent zinc metalloprotease FtsH
EC 3.4.24.-
Gene Name ftsH BARBAKC583_0168
Organism Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Alphaproteobacteria Hyphomicrobiales Bartonellaceae Bartonella Bartonella bacilliformis Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)
Enzyme Sequence MNSNFRSLMIWGLIALFLIVLFSFFNGNRQRASNGEVSYSEFLQKIDNNELKTVTIQGQKLTGQTADRRMISTYAPRDPGLVQRLNTNKVNIRAVPESSGNSIFLNLLFSLLPVLIIVGAWIFFMRQMQGGSRGALGFGKSKAKLLTEAQGRVTFKDVAGVEEAKQDLQEIVDFLREPQKFQRLGGRIPRGVLLVGPPGTGKTLLARSIAGEANVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFIDEIDAVGRHRGAGLGGGNDEREQTLNQLLVEMDGFEPNESIILIAATNRPDVLDPALLRPGRFDRQVVVPNPDVAGREKILEVHVRNVPLAPNVNLRVLARGTPGFSGADLMNLVNEAALMAASRNKKVVTMQEFEDAKDKVMMGAERRSTAMTQEEKELTAYHEAGHAIVALNVPVSDPVHKATIVPRGRALGMVMQLPEGDRYSMSYLWMVSRLAIMMGGRVAEELKFGKENITSGAASDIEQATKLARAMITRWGFSDMLGHVAYGDNQDEIFLGHSVARTQNISEETARMIDAEVRRLIDDAYKTATKILKTQNKQWLALAQGLLEYETLTGTEINEVIAGKPPSRTQGSDTAPLRTSSVPKIGAKNSKGASKSGDAEETEPSVGTKATAASSAKKVVKNASAKSAEKKASGTQVKAATPAATSIKATSAKVASAKAETENVASAQAATENVAMVKAATANVAKKSVESAQADDAEKKRLEEHNKSAHNKKGNLTAGAASNTEDEK
Enzyme Length 764
Uniprot Accession Number A1URA3
Absorption
Active Site ACT_SITE 419; /evidence=ECO:0000255|HAMAP-Rule:MF_01458
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. {ECO:0000255|HAMAP-Rule:MF_01458}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding NP_BIND 196..203; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_01458
Features Active site (1); Chain (1); Compositional bias (3); Metal binding (3); Nucleotide binding (1); Region (2); Topological domain (3); Transmembrane (2)
Keywords ATP-binding;Cell inner membrane;Cell membrane;Hydrolase;Membrane;Metal-binding;Metalloprotease;Nucleotide-binding;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01458}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01458}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_01458}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 82,521
Kinetics
Metal Binding METAL 418; /note=Zinc; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_01458; METAL 422; /note=Zinc; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_01458; METAL 496; /note=Zinc; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_01458
Rhea ID
Cross Reference Brenda