IED ID | IndEnz0002018680 |
Enzyme Type ID | protease018680 |
Protein Name |
ATP-dependent zinc metalloprotease FTSH 1, chloroplastic AtFTSH1 EC 3.4.24.- |
Gene Name | FTSH1 AAA FTSH At1g50250 F14I3.14 |
Organism | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
Enzyme Sequence | MASNSLLRSSSNFFLGSHIIISSPTPKTTRKPSFPFSFVSRAKYQITRSSQDENSPNGKPNSPFSSQVALAAILLSSISSSPLALAVVDEPASPSVVIESQAVKPSTPSPLFIQNEILKAPSPKSSDLPEGSQWRYSEFLNAVKKGKVERVRFSKDGSVVQLTAVDNRRASVIVPNDPDLIDILAMNGVDISVSEGESSGNDLFTVIGNLIFPLLAFGGLFLLFRRAQGGPGGGPGGLGGPMDFGRSKSKFQEVPETGVSFADVAGADQAKLELQEVVDFLKNPDKYTALGAKIPKGCLLVGPPGTGKTLLARAVAGEAGVPFFSCAASEFVELFVGVGASRVRDLFEKAKSKAPCIVFIDEIDAVGRQRGAGMGGGNDEREQTINQLLTEMDGFSGNSGVIVLAATNRPDVLDSALLRPGRFDRQVTVDRPDVAGRVKILQVHSRGKALGKDVDFDKVARRTPGFTGADLQNLMNEAAILAARRELKEISKDEISDALERIIAGPEKKNAVVSEEKKRLVAYHEAGHALVGALMPEYDPVAKISIIPRGQAGGLTFFAPSEERLESGLYSRSYLENQMAVALGGRVAEEVIFGDENVTTGASNDFMQVSRVARQMIERFGFSKKIGQVAVGGPGGNPFMGQQMSSQKDYSMATADIVDAEVRELVEKAYKRATEIITTHIDILHKLAQLLIEKETVDGEEFMSLFIDGQAELYIS |
Enzyme Length | 716 |
Uniprot Accession Number | Q39102 |
Absorption | |
Active Site | ACT_SITE 525; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.24.- |
Enzyme Function | FUNCTION: Part of a complex that function as an ATP-dependent zinc metallopeptidase. Involved in the thylakoid formation and in the removal of damaged D1 in the photosystem II, preventing cell death under high-intensity light conditions. {ECO:0000269|PubMed:10715327}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | NP_BIND 302..309; /note=ATP; /evidence=ECO:0000255 |
Features | Active site (1); Chain (1); Frameshift (1); Metal binding (3); Nucleotide binding (1); Sequence conflict (12); Transit peptide (2); Transmembrane (1) |
Keywords | ATP-binding;Chloroplast;Developmental protein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Nucleotide-binding;Plastid;Protease;Reference proteome;Thylakoid;Transit peptide;Transmembrane;Transmembrane helix;Ubl conjugation;Zinc |
Interact With | |
Induction | INDUCTION: By high light. {ECO:0000269|PubMed:15266057}. |
Subcellular Location | SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:8910594}; Single-pass membrane protein {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:8910594}; Stromal side {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:8910594}. |
Modified Residue | |
Post Translational Modification | PTM: The FTSH1 precursor is ubiquitinated by CHIP in the cytoplasm. {ECO:0000269|PubMed:17714429}. |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 10849347; 11719511; 12185496; 14576160; 14740254; 15028209; 15276459; 15322131; 15489341; 16157880; 16603408; 16640601; 17181860; 17217462; 17432890; 18230142; 18633119; 19228339; 20921219; 21062893; 21214651; 22121866; 23548781; 26909098; 29973948; 30131421; 31552075; 32344669; |
Motif | |
Gene Encoded By | |
Mass | 76,759 |
Kinetics | |
Metal Binding | METAL 524; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 528; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 605; /note=Zinc; catalytic; /evidence=ECO:0000250 |
Rhea ID | |
Cross Reference Brenda | 3.4.24.B20; |