| IED ID | IndEnz0002018693 |
| Enzyme Type ID | protease018693 |
| Protein Name |
Dipeptidyl peptidase family member 1 EC 3.4.14.- |
| Gene Name | dpf-1 T23F1.7 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MTAEADLLEGYDEELGGNESQKRDCKGITTAIVVVLLILVMIFAALVFFTPLFAAKSFGSWRLNVSDLRSLRYPYAEFAFTDNNAVVMQSWEGVEIVEDGVSRLIFGRENGAEITPSADRKYFAMMDHAPNPGMNPQNETFHLKIVNNNERLNPLLPFEVEELFRELSDSRITYDIGLRKEESVIQAFKWNGKFNDFVFVESNKIYYQSSPEEEGLTRVSNGGEHTVDGLFDWIYEEEIFGRKDAMWWSTKGDQLAYASYDNHLTKNVSLKTYHRLEPYPIDTNFHYPKTFAKVLPTYTLSIWNKKTEQSRQLDVQLKDSLSYHYLLAVKWLEINGTEQLVSVWTNRYQNEVALTICDWDTAICRLEFEYKYASKRWVTHDDFHSITSFEDTLFFLLPHDKRDNAFQQVASLRLSHGQLRTPKFLNLGEYDVTSINGINKETRTIFFHAAAPKPSHRSLFSYSLADESRNSAYCISCSIKNCTWAQAQMDDQMKTAIVSCKGPAAPHTAIVNLTRMDSDKKTEHANLLYDKTYQNRVEEAGLPVIIKETIKISDDFDALIKLSIPKDIYNRDKHQAIPLIVHVYGGPNDQNTKEATQIGIEEVVASASQAAILRIDGRGSGGRGWKYRSAIYGQLGTVEVEDQIKAIKVVLRLYRHLLDARRVAVFGWSYGGFMTLSMVNEAPEQFFKCAVSVAPVTNFAYYDATYTERYMGDAPLESYSDVTKKLDNFKSTRLLLMHGLLDDNVHFQNSAILIDELQNRGVDFDLMVYPNQAHSLSSRTSHVVGKMTHFLRQCFYTDK |
| Enzyme Length | 799 |
| Uniprot Accession Number | Q7JKY3 |
| Absorption | |
| Active Site | ACT_SITE 669; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 742; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 774; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.14.- |
| Enzyme Function | FUNCTION: Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration. {ECO:0000250, ECO:0000269|Ref.2}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (1); Disulfide bond (3); Glycosylation (6); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Aminopeptidase;Cell membrane;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17164286; 19343510; 21177967; 21367940; 22286215; 22347378; 22560298; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 91,365 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |