| IED ID | IndEnz0002018705 |
| Enzyme Type ID | protease018705 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 17 homolog ADAM 17 homolog EC 3.4.24.- |
| Gene Name | adm-4 ZK154.7 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MKIQDRSLLIFLVLGILKSDAFNTRVKRHAPIRFQRSTRQSVVHFEFLDQEYVVDLEPNHSTFHENFKVFTQDGPQIVPRDEYIGTVREPRAGRAVLTQLEENVYIGSLYFVDDTLHLEPSYPHQLSDDLGPVVGYFESDLDLNLDLSAMPVRNQVSFRRANPFLKHRRAIAIPSDRRKDVLNVKRNRCTLKLVADYSFYSIFGKNNTGIVTKFLVNMIARVNEIYTPINWDVGKEDDISGRGRFQNMGFSIKEIKVLDRPNASDSHYNSYSRIWEVERLLREFAFAEGSKDFCLVHLVTARTFREVATLGLAYVSYKKWDETAGGICSKQETFNGRVAYINVLLSTSFANSEQSTYPLITKEIDIVVSHEYGHAWGATHDPTIDSDDPDVEECSPNDQNGGKYLMSQYAQKGYDANNVLFSPCSRKLIRDVLIGKWESCFQEEMTSFCGNGIVEDGEECDNGVDTDNEFNCCDKFCRLAVGAKCSPLNHICCTPTCQFHNSTHVCLPGDSLLCKADAVCNGFSGECPSAPPVRDGQECLEGGECLNGVCLPFCEKMSIGKKSCICEDLELSCRLCCRDYNGTCAPVPGHVYLRDGVRCSKGSCRDRKCVNEVVDNVRNYFLITFQTTGGVLEFIKTHIVVIAIIFFTLIFVGIYKIVKYGENFTEKVTHKTAGGCRSVFVKADVN |
| Enzyme Length | 686 |
| Uniprot Accession Number | Q94316 |
| Absorption | |
| Active Site | ACT_SITE 371; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Metalloprotease (By similarity). Acts together with protease sup-17 to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision (PubMed:16197940). By modulating glp-1/Notch signaling, plays a role in germline development (PubMed:16197940). {ECO:0000250|UniProtKB:P78536, ECO:0000269|PubMed:16197940}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (3); Domain (2); Glycosylation (5); Metal binding (3); Propeptide (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Cell membrane;Cleavage on pair of basic residues;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11231151; 15338614; 17486083; 17850180; 17897480; 20439776; 21177967; 22286215; 22560298; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 77,299 |
| Kinetics | |
| Metal Binding | METAL 370; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 374; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 380; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Rhea ID | |
| Cross Reference Brenda |