Detail Information for IndEnz0002018726
IED ID IndEnz0002018726
Enzyme Type ID protease018726
Protein Name Carboxypeptidase Y homolog A
EC 3.4.16.5
Gene Name CPYA HCAG_08666
Organism Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Ajellomycetaceae Histoplasma Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum) Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Enzyme Sequence MKSSLALALLVGGAIASGPQQQVLREPVDHPQAAETPLQKISDIFGHLSEQAGNVWEDVMDKFPDTLMDAITQTPPPKKHNRRPDSEWDHIVRGSDVQAVWVEGDAGEKHRKVGGRLDTYDLRVKAVDPSNLGVDTVKQYSGYLDDNENDKHLFYWFFESRNDPKNDPVVLWLNGGPGCSSLTGLFLELGPSSITKQLKVEYNEFSWNSNASVIFLDQPVNVGYSYSSSSVSNTQAAAKDVYALLTLFFEQFPEYSRQDFHIAGESYAGHYIPVFASEIMSHSHRNINLKSILVGNGLTDPLSQYPHYRPMACGEGGYPAVLSSSSCQAMDNALPRCLAMIQACYNTESRWSCVPASIYCNNALIGPYQRSGMNPYDVRSKCEGGSLCYTQLDDISKYLNRNAVMESLGAEVSSYESCNMDINRNFLFQGDWMQPYMRVVPTLLAQMPVLIYAGDADFICNWLGNKAWTEALEYPGHNEFAAAEMKNLTSQNHEDVRVIGQVKSAGNFTFMRLFGGGHMVPMDQPEASLEFFNRWLGGEWSDKSP
Enzyme Length 545
Uniprot Accession Number A6RGA0
Absorption
Active Site ACT_SITE 266; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 457; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 518; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of a C-terminal amino acid with broad specificity.; EC=3.4.16.5; Evidence={ECO:0000255|PROSITE-ProRule:PRU10074};
DNA Binding
EC Number 3.4.16.5
Enzyme Function FUNCTION: Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (5); Glycosylation (3); Propeptide (1); Signal peptide (1)
Keywords Carboxypeptidase;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Signal;Vacuole;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..18; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 60,747
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda