| IED ID |
IndEnz0002018742 |
| Enzyme Type ID |
protease018742 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 5
|
| Gene Name |
ADAM5 |
| Organism |
Cavia porcellus (Guinea pig) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Glires (Rodents and rabbits)
Rodentia
Hystricomorpha
Caviidae (cavies)
Cavia (guinea pigs)
Cavia porcellus (Guinea pig)
|
| Enzyme Sequence |
MFLVLVLLTGLGRLYAGNNPRKTFVQTTVPERISSVDTRRHLEHNVAYNITLKGKSYVVRLKKESFLSSGSVIYFYDNRGVQRSQPLLPEMDCSYSGYVAGFPHSRVVFATCLGLRGVIQFENVSYAIEPLEVLSGFTHMIYEENNDNTHVPLFGKNNSYARIHNLESQGRRSVHKTTVSKLSPRYIDMYIVVNKNLFDYLGSDIKTVTQKIIQVIGLVNAMFTQLKLHVLISSIEIWSRSNKVTNTRRPDDDLFRFSDWKRKHVSLKSHYVAYLLTFDKYPESIGATFPENICNEEYASGIAVYPAGLSLESFAVIIVQLLSLSAGVMYDTSDSCYCSTDVCTMTQEAVFASGLKDFSTCSMDNFKYFASQYGLTCLRNTSYDMPIYKQFPPRRRRICGNSIREEGEECDCGTLRNCTHKKCCDPMQCRMKKGAKCGTGPCCTVDCQFQKANVLCRKSVDKDCDFDEYCNGRSGDCVHDTYAQNGHFCDSGGAFCFNGRCRTHDRQCQALIGGDSRGAPFACYDEVNSRGDVYGNCGRHQCYIQHALCGKLVCTWPHKQLVSRVNLSVVYAHVRDDICVATTKTVRKIIRDLSLTTVLLPEDRDETFVEDGTICGPGQYCDKWFCKEVQFINNGSCNAEIHCQGRGICNNLDNCHCHKGFVPPECAPKKGQFGSLDDGHLVETTKTSGFRKINMRRGYVVLSTKRFQLIFYIGIPVIIIVAAILIKQNQLGKLFCRGEKEHMSSVSEDGSRSVTLSATESKFPADTEHSNKEEDAQ |
| Enzyme Length |
777 |
| Uniprot Accession Number |
Q60472 |
| Absorption |
|
| Active Site |
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| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). {ECO:0000250}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (1); Disulfide bond (7); Domain (3); Glycosylation (3); Propeptide (1); Region (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords |
Disulfide bond;EGF-like domain;Glycoprotein;Membrane;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Subject to proteolytic processing during epididymal transit of spermatozoa. {ECO:0000250}. |
| Signal Peptide |
SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
87,407 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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