Detail Information for IndEnz0002018762
IED ID IndEnz0002018762
Enzyme Type ID protease018762
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs adt-2
ADAMTS adt-2
EC 3.4.24.-
Gene Name adt-2 sma-21 F08C6.1
Organism Caenorhabditis elegans
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans
Enzyme Sequence MLLPLLISGLLFRNADAFLPFFNEDDLKYTFGVDTHAEVPNHEEIDPVPYYHQNGSLHKLEFMAFNKKYNLSLEPTLAKLLSSGVTVVKKNEKKGGSLDFGSTLDSCHYHHYGEKVYAAISNCDGRIKGTVIDDGEIIVVHPFPDHHAHRSKRATENGAHVVYKRETLAGEPKDFCGLDNVVTEESLVEDESAIFEDVFVTGQRLTQQSDLIVELAVFVDENLWRHFSSKHGGMADRKLQDYTLTLLNNIQIMYYQPTASPPLTFRVIRYEVLTRQPSALAGYLHNHGNAQMYLDRFCRYQRNLAVRDWDHAIMLTGYDIHRGAGSRSISGIARLDGMCDPWNTCTLAEGLDFTSAFIGTHELGHSVGMRHDEPYCQSKHIMSSSLGPGKVTWSTCSLRDYHQFLQRLDGRGKNCLRVSNMPNKLEISSNVKPGQIYDANLQCELMHGNGYQQVTPRQDSYDGICYMMWCGQSSFGRIITSHPALEGTFCGPSKWCQLGRCVPWTGTNEIQPTVQHVAPVVTTLPSRIDGSWSGWGATICSQCTCNGILGSVGLAIARRTCSAPYPANGGSDCVGSTSRAVLCSRQCGRASKSVDEYISDKCMEQKRLKNDRELTGKGSQLNRFPQRACKVFCDVQQHYGSQRNYRFFGDNLPDGTSCGYDRYCLDGECLALNCNNNALISRDQSCPTDTCPITDQSSSVYRGQWGTWSLWTSCTATCGGGYRKRNRACSITGQCEGNEDETEVCSSESCPSVLRVGNEWSTWTEWNHCSVSCGRGSQARYRKCLSPHRTLAFDCPEKNIEVRSCDNGPCNAIGVWGTWGGWSTCSTSCGPGTLVRQRTCNREPCDGSAHERRSCNVATCQNDGIWSLWNEWSDCSRVCGKGLRSRSRSCFGSGCMGASSEQQFCNEQACASSSANDWGTWSGWSQCSVSCGAGVKRRTRTCRTGNCPGNYKESAICNDRDCENKNAAWGGWGYWSSCSETCGDGVRKRVRKCYGSGNCDGQQYEKQYCNLRVCDFRRKF
Enzyme Length 1020
Uniprot Accession Number Q19204
Absorption
Active Site ACT_SITE 362; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Regulates body size probably independently of the TGF beta-like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. {ECO:0000269|PubMed:21256840}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (19); Domain (8); Glycosylation (2); Metal binding (3); Motif (1); Mutagenesis (1); Propeptide (1); Signal peptide (1)
Keywords Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Secreted;Signal;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..17; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10778742; 11381264; 12529635; 14551910; 14704431; 15791247; 16122351; 17164286; 18425118; 19343510; 20439774; 20439776; 21177967; 22267497; 22347378; 22500807; 22560298; 23800452; 24884423; 25487147; 6593563;
Motif MOTIF 174..181; /note=Cysteine switch; /evidence=ECO:0000250|UniProtKB:P03956
Gene Encoded By
Mass 113,527
Kinetics
Metal Binding METAL 361; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 365; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 371; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276
Rhea ID
Cross Reference Brenda