Detail Information for IndEnz0002018763
IED ID IndEnz0002018763
Enzyme Type ID protease018763
Protein Name Major pepsin inhibitor 3
PI-3
Gene Name
Organism Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Spirurina Ascaridomorpha Ascaridoidea Ascarididae Ascaris Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Enzyme Sequence MHVWLILSLASLWTSSIAYSQFLFSMSTGPFICTVKDNQVFVANLPWTMLEGDDIQVGKEFAARVEDCTNVKHDMAPTCTKPPPFCGPQDMKMFNFVGCSVLGNKLFIDQKYVRDLTAKDHAEVQTFREKIAAFEEQQENQPPSSGMPHGAVPAGGLSPPPPPSFCTVQ
Enzyme Length 169
Uniprot Accession Number P19400
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: This is an inhibitor of the aspartic protease pepsin.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (8); Chain (1); Compositional bias (1); Disulfide bond (3); Helix (6); Modified residue (1); Region (1); Signal peptide (1)
Keywords 3D-structure;Aspartic protease inhibitor;Direct protein sequencing;Disulfide bond;Protease inhibitor;Pyrrolidone carboxylic acid;Secreted;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue MOD_RES 21; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:2223768
Post Translational Modification
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000269|PubMed:2223768
Structure 3D X-ray crystallography (2)
Cross Reference PDB 1F32; 1F34;
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 18,657
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda