Detail Information for IndEnz0002018779
IED ID IndEnz0002018779
Enzyme Type ID protease018779
Protein Name Amyloid beta precursor like protein 2
APPH
Amyloid beta
A4
precursor-like protein 2
Amyloid protein homolog
Amyloid-like protein 2
APLP-2
CDEI box-binding protein
CDEBP
Sperm membrane protein YWK-II
Gene Name APLP2 APPL2
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
Enzyme Length 763
Uniprot Accession Number Q06481
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). {ECO:0000250, ECO:0000269|PubMed:8307156}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (5); Beta strand (3); Chain (1); Compositional bias (3); Disulfide bond (9); Domain (3); Frameshift (1); Helix (10); Metal binding (3); Modified residue (1); Motif (1); Natural variant (1); Region (4); Sequence conflict (4); Signal peptide (1); Site (2); Topological domain (2); Transmembrane (1); Turn (2)
Keywords 3D-structure;Alternative splicing;Cell membrane;Copper;DNA-binding;Disulfide bond;Glycoprotein;Membrane;Metal-binding;Nucleus;Phosphoprotein;Protease inhibitor;Reference proteome;Serine protease inhibitor;Signal;Transmembrane;Transmembrane helix
Interact With P51693; Itself; P05067-4; O75618; P14921; P05412; Q93074; P02649; P05067; Q96GW7; Q13867; Q9BS26; Q06787-7; P06241; P14136; Q14114-3; Q96L34; P17252; P23443; P04271; Q8IUQ4-2; P84022; Q13190; P43405-2; Q13428-5; Q9BX74; Q9BVJ6
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.
Modified Residue MOD_RES 590; /note=Phosphoserine; by FAM20C; /evidence=ECO:0000269|PubMed:26091039
Post Translational Modification PTM: The BPTI/Kunitz inhibitor domain is O-glycosylated. {ECO:0000269|PubMed:8307156}.
Signal Peptide SIGNAL 1..31; /evidence=ECO:0000255
Structure 3D X-ray crystallography (2)
Cross Reference PDB 5JBT; 5TPT;
Mapped Pubmed ID 12228233; 12595709; 14597230; 14699153; 14970211; 14970212; 14983046; 15208260; 15231748; 15584916; 16193067; 16279945; 16645641; 17405931; 17452623; 17709753; 18452037; 18641335; 19126676; 19808674; 20195357; 20379614; 20711500; 20732423; 20936779; 20953506; 21178287; 21293490; 21695060; 21826533; 21952790; 21988832; 22641691; 22797723; 23430252; 25683482; 26085104; 26313004; 26496610; 27796194; 27810896; 29663738; 30608876; 30810435; 32716039; 8467233; 9109675; 9461550;
Motif MOTIF 750..755; /note=NPXY motif
Gene Encoded By
Mass 86,956
Kinetics
Metal Binding METAL 163; /note=Copper; /evidence=ECO:0000255|PROSITE-ProRule:PRU01217; METAL 167; /note=Copper; /evidence=ECO:0000255|PROSITE-ProRule:PRU01217; METAL 184; /note=Copper; /evidence=ECO:0000255|PROSITE-ProRule:PRU01217
Rhea ID
Cross Reference Brenda