Detail Information for IndEnz0002018826
IED ID IndEnz0002018826
Enzyme Type ID protease018826
Protein Name Bradykinin-potentiating peptide 11g
BPP-11g
Gene Name
Organism Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai)
Enzyme Sequence QARPRHPKIPP
Enzyme Length 11
Uniprot Accession Number P0DL00
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: This peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it. It acts as an indirect hypotensive agent (By similarity). {ECO:0000250, ECO:0000269|PubMed:22869554}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Modified residue (1); Peptide (1); Sequence uncertainty (2)
Keywords Direct protein sequencing;Hypotensive agent;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Pyrrolidone carboxylic acid;Secreted;Toxin
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue MOD_RES 1; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:22869554
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 1,297
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda