IED ID | IndEnz0002018832 |
Enzyme Type ID | protease018832 |
Protein Name |
Bradykinin-potentiating peptide 10d BPP-10d |
Gene Name | |
Organism | Bothrops cotiara (Cotiara) (Rhinocerophis cotiara) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops cotiara (Cotiara) (Rhinocerophis cotiara) |
Enzyme Sequence | QNWPHPPMPP |
Enzyme Length | 10 |
Uniprot Accession Number | P0DJK2 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: This peptide evokes slight hypotension (-2 mmHg), when injected alone into rats. It has no bradykinin-potentiating effect, when 60 nmol of BPP-10d are coinjected with 0.5 ug of bradykinin into rats. It inhibits angiotensin converting enzyme (ACE) activity with a K(i)app of 9.12 uM. {ECO:0000269|PubMed:22869554}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Modified residue (1); Peptide (1) |
Keywords | Direct protein sequencing;Hypotensive agent;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Pyrrolidone carboxylic acid;Secreted;Toxin |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
Modified Residue | MOD_RES 1; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:22869554 |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 1,200 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |