Detail Information for IndEnz0002018833
IED ID IndEnz0002018833
Enzyme Type ID protease018833
Protein Name Bradykinin-potentiating peptide F
AppF
BPP-F
Gene Name
Organism Agkistrodon piscivorus piscivorus (Eastern cottonmouth)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Agkistrodon Agkistrodon piscivorus (cottonmouth) Agkistrodon piscivorus piscivorus (Eastern cottonmouth)
Enzyme Sequence QLWPRPHIPP
Enzyme Length 10
Uniprot Accession Number P0C7R6
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: This peptide potentiates the effect of bradykinin on the isolated guinea-pig ileum, does not potentiate the effects of bradykinin upon blood pressure and inhibits the angiotensin-converting enzyme (ACE) from rat plasma. {ECO:0000269|PubMed:8599182}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Modified residue (1); Peptide (1)
Keywords Direct protein sequencing;Hypotensive agent;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Pyrrolidone carboxylic acid;Secreted
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8599182}.
Modified Residue MOD_RES 1; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:8599182
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 1,240
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda