IED ID | IndEnz0002018834 |
Enzyme Type ID | protease018834 |
Protein Name |
Bradykinin-potentiating peptide AP BPP-AP Cleaved into: Bradykinin-potentiating peptide 11e BPP-11e |
Gene Name | |
Organism | Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai) |
Enzyme Sequence | QARPPHPPIPPAP |
Enzyme Length | 13 |
Uniprot Accession Number | P0DKZ9 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: This peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it. It acts as an indirect hypotensive agent (By similarity). {ECO:0000250, ECO:0000269|PubMed:22869554}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Modified residue (1); Peptide (2); Sequence uncertainty (1) |
Keywords | Direct protein sequencing;Hypotensive agent;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Pyrrolidone carboxylic acid;Secreted;Toxin |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
Modified Residue | MOD_RES 1; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:22869554 |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 1,375 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |