Detail Information for IndEnz0002018839
IED ID IndEnz0002018839
Enzyme Type ID protease018839
Protein Name Procathepsin L
EC 3.4.22.15
Cathepsin L1

Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain; Cathepsin L
Fragments
Gene Name CTSL CTSL1
Organism Gallus gallus (Chicken)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken)
Enzyme Sequence APRSVDWREKGYVTPVKDQGQCGSCWAFSTTGALEGQHFRTKGKLVSLSEQNLVDCSRPEGNQGCNGGLMDQAFQYVQDNGGIDSEESYPYTAKDDEDCRYKAEYNAANDTGFVDIPQGHERALMKAVASVGPVSVAIDAGHSSFQFYQSGIYYEPDCSSEDLDHGVLVVGYGFEGGKKYWIVKNSWGEKWGDKGYIYMAKDRKNHCGIATAASYPLV
Enzyme Length 218
Uniprot Accession Number P09648
Absorption
Active Site ACT_SITE 25; /evidence=ECO:0000250; ACT_SITE 165; /evidence=ECO:0000250; ACT_SITE 185; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.; EC=3.4.22.15;
DNA Binding
EC Number 3.4.22.15
Enzyme Function FUNCTION: Important for the overall degradation of proteins in lysosomes.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (3); Disulfide bond (3); Non-adjacent residues (1); Sequence conflict (7)
Keywords Cell membrane;Cytoplasmic vesicle;Direct protein sequencing;Disulfide bond;Hydrolase;Lysosome;Membrane;Protease;Reference proteome;Secreted;Thiol protease
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P06797}. Apical cell membrane {ECO:0000250|UniProtKB:P06797}; Peripheral membrane protein {ECO:0000250|UniProtKB:P06797}; Extracellular side {ECO:0000250|UniProtKB:P06797}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:P25975}. Secreted, extracellular space {ECO:0000250|UniProtKB:P06797}. Secreted {ECO:0000250|UniProtKB:P06797}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 23,963
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda