| IED ID |
IndEnz0002018847 |
| Enzyme Type ID |
protease018847 |
| Protein Name |
Endothiapepsin
EC 3.4.23.22
Aspartate protease
|
| Gene Name |
EAPA EPN-1 |
| Organism |
Cryphonectria parasitica (Chestnut blight fungus) (Endothia parasitica) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Pezizomycotina
leotiomyceta
sordariomyceta
Sordariomycetes
Sordariomycetidae
Diaporthales
Cryphonectriaceae
Cryphonectria-Endothia species complex
Cryphonectria
Cryphonectria parasitica (Chestnut blight fungus) (Endothia parasitica)
|
| Enzyme Sequence |
MSSPLKNALVTAMLAGGALSSPTKQHVGIPVNASPEVGPGKYSFKQVRNPNYKFNGPLSVKKTYLKYGVPIPAWLEDAVQNSTSGLAERSTGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK |
| Enzyme Length |
419 |
| Uniprot Accession Number |
P11838 |
| Absorption |
|
| Active Site |
ACT_SITE 124; ACT_SITE 288 |
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins with specificity similar to that of pepsin A, prefers hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk.; EC=3.4.23.22; |
| DNA Binding |
|
| EC Number |
3.4.23.22 |
| Enzyme Function |
|
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Active site (2); Beta strand (29); Chain (1); Disulfide bond (1); Domain (1); Helix (8); Propeptide (1); Signal peptide (1); Turn (4) |
| Keywords |
3D-structure;Aspartyl protease;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Signal;Zymogen |
| Interact With |
|
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D |
Neutron diffraction (2); X-ray crystallography (739) |
| Cross Reference PDB |
1E5O;
1E80;
1E81;
1E82;
1EED;
1ENT;
1EPL;
1EPM;
1EPN;
1EPO;
1EPP;
1EPQ;
1EPR;
1ER8;
1GKT;
1GVT;
1GVU;
1GVV;
1GVW;
1GVX;
1OD1;
1OEW;
1OEX;
2ER0;
2ER6;
2ER7;
2ER9;
2JJI;
2JJJ;
2V00;
2VS2;
3ER3;
3ER5;
3LZY;
3PB5;
3PBD;
3PBZ;
3PCW;
3PCZ;
3PGI;
3PI0;
3PLD;
3PLL;
3PM4;
3PMU;
3PMY;
3PRS;
3PSY;
3PWW;
3Q6Y;
3T6I;
3T7P;
3T7Q;
3T7X;
3URI;
3URJ;
3URL;
3WZ6;
3WZ7;
3WZ8;
4APE;
4ER1;
4ER2;
4ER4;
4KUP;
4L6B;
4LAP;
4LBT;
4LHH;
4LP9;
4Y35;
4Y36;
4Y37;
4Y38;
4Y39;
4Y3A;
4Y3D;
4Y3E;
4Y3F;
4Y3G;
4Y3H;
4Y3J;
4Y3L;
4Y3M;
4Y3N;
4Y3P;
4Y3Q;
4Y3R;
4Y3S;
4Y3T;
4Y3W;
4Y3X;
4Y3Y;
4Y3Z;
4Y41;
4Y43;
4Y44;
4Y45;
4Y47;
4Y48;
4Y4A;
4Y4B;
4Y4D;
4Y4E;
4Y4G;
4Y4J;
4Y4T;
4Y4U;
4Y4W;
4Y4X;
4Y4Z;
4Y50;
4Y51;
4Y53;
4Y54;
4Y56;
4Y57;
4Y58;
4Y5A;
4Y5B;
4Y5C;
4Y5E;
4Y5G;
4Y5K;
4Y5L;
4Y5M;
4Y5N;
4Y5P;
4YCK;
4YCT;
4YCY;
4YD3;
4YD4;
4YD5;
4YD6;
4YD7;
4ZE6;
4ZEA;
5DPZ;
5DQ1;
5DQ2;
5DQ4;
5DQ5;
5DR0;
5DR1;
5DR3;
5DR4;
5DR7;
5DR8;
5ER1;
5ER2;
5HCO;
5HCT;
5IS4;
5ISJ;
5ISK;
5J25;
5LWR;
5LWS;
5LWT;
5LWU;
5MB0;
5MB3;
5MB5;
5MB6;
5MB7;
5OG7;
5OJE;
5OYQ;
5OYR;
5OYS;
5OYT;
5OYU;
5OYV;
5OYW;
5OYX;
5OYY;
5OYZ;
5OZ0;
5OZ1;
5OZ2;
5OZ3;
5OZ4;
5OZ5;
5OZ6;
5OZ7;
5OZ8;
5OZ9;
5OZA;
5OZB;
5OZC;
5OZD;
5OZE;
5OZF;
5OZG;
5OZH;
5OZI;
5OZJ;
5OZK;
5OZL;
5OZM;
5OZN;
5OZO;
5OZP;
5OZQ;
5OZR;
5OZS;
5OZT;
5OZU;
5OZV;
5OZW;
5OZX;
5OZY;
5OZZ;
5P00;
5P01;
5P02;
5P03;
5P04;
5P05;
5P06;
5P07;
5P08;
5P09;
5P0A;
5P0B;
5P0C;
5P0D;
5P0E;
5P0F;
5P0G;
5P0H;
5P0I;
5P0J;
5P0K;
5P0L;
5P0M;
5P0N;
5P0O;
5P0P;
5P0Q;
5P0R;
5P0S;
5P0T;
5P0U;
5P0V;
5P0W;
5P0X;
5P0Y;
5P0Z;
5P10;
5P11;
5P12;
5P13;
5P14;
5P15;
5P16;
5P17;
5P18;
5P19;
5P1A;
5P1B;
5P1C;
5P1D;
5P1E;
5P1F;
5P1G;
5P1H;
5P1I;
5P1J;
5P1K;
5P1L;
5P1M;
5P1N;
5P1O;
5P1P;
5P1Q;
5P1R;
5P1S;
5P1T;
5P1U;
5P1V;
5P1W;
5P1X;
5P1Y;
5P1Z;
5P20;
5P22;
5P23;
5P24;
5P25;
5P26;
5P27;
5P28;
5P29;
5P2A;
5P2B;
5P2C;
5P2D;
5P2E;
5P2F;
5P2G;
5P2H;
5P2I;
5P2J;
5P2K;
5P2L;
5P2M;
5P2N;
5P2O;
5P2Q;
5P2R;
5P2S;
5P2T;
5P2U;
5P2V;
5P2W;
5P2X;
5P2Y;
5P2Z;
5P30;
5P31;
5P32;
5P33;
5P34;
5P35;
5P36;
5P37;
5P38;
5P39;
5P3A;
5P3B;
5P3C;
5P3D;
5P3E;
5P3F;
5P3G;
5P3H;
5P3I;
5P3J;
5P3K;
5P3L;
5P3M;
5P3N;
5P3O;
5P3P;
5P3Q;
5P3R;
5P3S;
5P3T;
5P3U;
5P3V;
5P3W;
5P3X;
5P3Y;
5P3Z;
5P40;
5P41;
5P42;
5P43;
5P44;
5P45;
5P46;
5P47;
5P48;
5P49;
5P4A;
5P4B;
5P4C;
5P4D;
5P4E;
5P4F;
5P4G;
5P4H;
5P4I;
5P4J;
5P4K;
5P4L;
5P4M;
5P4N;
5P4O;
5P4P;
5P4Q;
5P4R;
5P4S;
5P4T;
5P4U;
5P4V;
5P4W;
5P4X;
5P4Y;
5P4Z;
5P50;
5P51;
5P52;
5P53;
5P54;
5P55;
5P56;
5P57;
5P58;
5P59;
5P5A;
5P5B;
5P5C;
5P5D;
5P5E;
5P5F;
5P5G;
5P5H;
5P5I;
5P5J;
5P5K;
5P5L;
5P5M;
5P5N;
5P5O;
5P5P;
5P5Q;
5P5R;
5P5S;
5P5T;
5P5U;
5P5V;
5P5W;
5P5X;
5P5Y;
5P5Z;
5P60;
5P61;
5P62;
5P63;
5P64;
5P65;
5P66;
5P67;
5P68;
5P69;
5P6A;
5P6B;
5P6C;
5P6D;
5P6E;
5P6F;
5P6G;
5P6H;
5P6I;
5P6J;
5P6K;
5P6L;
5P6M;
5P6N;
5P6O;
5P6P;
5P6Q;
5P6R;
5P6S;
5P6T;
5P6U;
5P6V;
5P6W;
5P6X;
5P6Y;
5P6Z;
5P70;
5P71;
5P72;
5P73;
5P74;
5P75;
5P76;
5P77;
5P78;
5P79;
5P7A;
5P7B;
5P7C;
5P7D;
5P7E;
5P7F;
5P7G;
5P7H;
5P7I;
5P7J;
5P7K;
5P7L;
5P7M;
5P7N;
5P7O;
5P7P;
5P7Q;
5P7R;
5P7S;
5P7T;
5P7U;
5P7V;
5P7W;
5P7X;
5P7Y;
5P7Z;
5P80;
5P81;
5P82;
5P83;
5P84;
5P85;
5P86;
5P87;
5P88;
5P89;
5P8A;
5P8B;
5P8C;
5P8D;
5P8E;
5P8F;
5P8G;
5P8H;
5P8I;
5P8J;
5P8K;
5P8L;
5P8M;
5P8N;
5P8O;
5P8P;
5P8Q;
5P8R;
5P8S;
5P8T;
5P8U;
5P8V;
5QB5;
5QB6;
5QB7;
5QB8;
5QB9;
5QBA;
5QBB;
5QBC;
5QBD;
5QBE;
5QBF;
5QBG;
5QBH;
5QBI;
5QBJ;
5QBK;
5QBL;
5QBM;
5QBN;
5QBO;
5QBP;
5QBQ;
5QBR;
5QBS;
5QBT;
5R1T;
5R1U;
5R1V;
5R1W;
5R1X;
5R1Y;
5R1Z;
5R20;
5R21;
5R22;
5R23;
5R24;
5R25;
5R26;
5R27;
5R28;
5R29;
5R2A;
5R2B;
5R2C;
5R2D;
5R2E;
5R2F;
5R2G;
5R2H;
5R2I;
5R2J;
5R2K;
5R2L;
5R2M;
5R2N;
5R2O;
5R2P;
5R2Q;
5R2R;
5R2S;
5R2T;
5R2U;
5R2V;
5R2W;
5R2X;
5R2Y;
5R2Z;
5R30;
5R31;
5R32;
5R33;
5R34;
5R35;
5R36;
5R37;
5R38;
5R39;
5R3A;
5R3B;
5R3C;
5R3D;
5R3E;
5R3F;
5R3G;
5R3H;
5R3I;
5R3J;
5R3K;
5R3L;
5R3M;
5R3N;
5R3O;
5R3P;
5R3Q;
5R3R;
5R3S;
5R3T;
5R3U;
5R3V;
5R3W;
5R3X;
5R3Y;
5R3Z;
5R40;
5R41;
5RBO;
5RBP;
5RBQ;
5RBR;
5RBS;
5RBT;
5RBU;
5RBV;
5RBW;
5RBX;
5RBY;
5RBZ;
5RC0;
5RC1;
5RC2;
5RC3;
5RC4;
5RC5;
5RC6;
5RC7;
5RC8;
5RC9;
5RCA;
5RCB;
5RCC;
5RCD;
5RCE;
5RCF;
5RCG;
5RCH;
5RCI;
5RCJ;
5RCK;
5RCL;
5RCM;
5RCN;
5RCO;
5RCP;
5RCQ;
5RCR;
5RCS;
5RCT;
5RCU;
5RCV;
5RCW;
5RCX;
5RCY;
5RCZ;
5RD0;
5RD1;
5RD2;
5RD3;
5RD4;
5RD5;
5RD6;
5RD7;
5RD8;
5RD9;
5RDA;
5RDB;
5RDC;
5RDD;
5RDE;
5RDF;
5RDG;
5RDH;
5RDI;
5RDJ;
5RDK;
5RDL;
5RDM;
5RDN;
5RDO;
5RDP;
5RDQ;
5RDR;
5RDS;
5RDT;
5RDU;
5RDV;
5RDW;
5RDX;
5RDY;
5RDZ;
5RE0;
5RE1;
5RE2;
5RE3;
5SAK;
5SAL;
5SAM;
5SAN;
5SAO;
5SAP;
5SAQ;
5SAR;
5SAS;
5SAT;
6RON;
6RSV;
6SCV;
6ZZ2;
7ADG;
|
| Mapped Pubmed ID |
11683623;
12777758;
12876323;
1304340;
1525155;
17985861;
18084100;
18479128;
21972967;
22213702;
22525752;
2266553;
24419612;
24532096;
25630461;
2690945;
27139825;
27400756;
27452405;
27463859;
27726357;
28097765;
30178575;
3119339;
32413289;
3295561;
34473087;
6381096;
7703859;
8254610;
8424781;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
43,255 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
3.4.23.22; |