Detail Information for IndEnz0002018853
IED ID IndEnz0002018853
Enzyme Type ID protease018853
Protein Name Carboxypeptidase Y homolog A
EC 3.4.16.5
Gene Name cpyA ScpC
Organism Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Enzyme Sequence MKFFTTGLLATAALAAAQEQQVLQAEDGMGRAPLPDSSIFDETLQKFQSSLEDGISHFWSEMKTNFKDYLPLISLPKKHTRRPDSEWDHVVRGADIESVWVQGADGEKRREIDGKLHNYDLRVKAVDPGVKQYSGYLDDNDADKHLFYWFFESRNDPKNDPVVLWLNGGPGCSSLTGLFLELGPATIDKNLKVVSNPYSWNSNASVIFLDQPVNVGFSYSGSSVSDTVAAGKDVYALLTLFFKQFPEYATQDFHISGESYAGHYIPVFAAEILSHKNTNINLKSALIGNGLTDPLTQYPQYRPMACGEGGYPAVLDQGTCRSMDNSLERCLSLIETCYSSESAWVCVPAAMYCNSAILAPYQQTGMNPYDVRTKCEDMASLCYPQLNAITEWLNQKPVMQALGVEVESYESCNSGINRDFLFHGDWMKPYHRLVPSVLEKIPVLIYAGDADFICNWLGNKAWTEALEWPGHKKFAETKLEDLKIVDNKNKGKKIGQVKSSGNFTFMRIFGAGHMVPLNQPEASLEFLNRWLRGEWH
Enzyme Length 536
Uniprot Accession Number Q5J6J0
Absorption
Active Site ACT_SITE 259; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 451; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 513; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of a C-terminal amino acid with broad specificity.; EC=3.4.16.5; Evidence={ECO:0000255|PROSITE-ProRule:PRU10074};
DNA Binding
EC Number 3.4.16.5
Enzyme Function FUNCTION: Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (5); Glycosylation (2); Propeptide (1); Signal peptide (1)
Keywords Carboxypeptidase;Disulfide bond;Glycoprotein;Hydrolase;Protease;Signal;Vacuole;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..17; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 60,099
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda