Detail Information for IndEnz0002018857
IED ID IndEnz0002018857
Enzyme Type ID protease018857
Protein Name Cathepsin Z
EC 3.4.18.1
Gene Name CTSZ
Organism Bos taurus (Bovine)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine)
Enzyme Sequence MASSGPLVPPLLLLLVLLAGAARAGLHFRPGRGCYRPLRGDRLTQLGRRTYPRPHEYLSPSDLPKSWDWRNVNGVNYASVTRNQHIPQYCGSCWAHGSTSAMADRINIKRKGAWPSTLLSVQHVIDCGDAGSCEGGNDLPVWEYAHRHGIPDETCNNYQAKDQECDKFNQCGTCTEFKECHVIKNYTLWKVGDYGSLSGREKMMAEIYTNGPISCGIMATEKMSNYTGGIYSEYNDQAFINHIVSVAGWGVSDGMEYWIVRNSWGEPWGEHGWMRIVTSTYKGGEGARYNLAIEESCTFGDPIV
Enzyme Length 304
Uniprot Accession Number P05689
Absorption
Active Site ACT_SITE 93; /evidence=ECO:0000255|PROSITE-ProRule:PRU10090; ACT_SITE 242; /evidence=ECO:0000255|PROSITE-ProRule:PRU10090; ACT_SITE 262; /evidence=ECO:0000255|PROSITE-ProRule:PRU10090
Activity Regulation ACTIVITY REGULATION: The disulfide bridge formed between Cys-34 in the propeptide and the active site residue Cys-93 may prevent activation of the zymogen through formation of a reversible covalent bond with the active site residue. {ECO:0000250|UniProtKB:Q9UBR2}.
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.; EC=3.4.18.1; Evidence={ECO:0000250|UniProtKB:Q9UBR2};
DNA Binding
EC Number 3.4.18.1
Enzyme Function FUNCTION: Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Capable of producing kinin potentiating peptides (By similarity). {ECO:0000250|UniProtKB:Q9R1T3, ECO:0000250|UniProtKB:Q9UBR2}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (6); Glycosylation (2); Propeptide (1); Signal peptide (1)
Keywords Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..24; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 33,886
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.18.1;