Detail Information for IndEnz0002018871
IED ID IndEnz0002018871
Enzyme Type ID protease018871
Protein Name Chymotrypsin-C
EC 3.4.21.2
Gene Name Ctrc
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MLGITVLAAILACASSCGDPTFPPNLSARVVGGEDAVPNSWPWQVSLQYLRDDTWRHTCGGSLITTSHVLTAAHCINTNLTYRVGLGKYNLTVEDEEGSVYAEVDTIYVHEKWNRLLLWNDIAIIKLAEPVELSDTIQVACIPEQDSLLPGDYPCYVTGWGRLWTNGPIAEVLQQGLQPIVNHTTCSRLDWWFIKVRETMVCAGGDGVISACNGDSGGPLNCPVEDGLWQVHGIVSFGSSRGCNTYKKPVVFTRVSAYIDWIKEKIQL
Enzyme Length 268
Uniprot Accession Number Q3SYP2
Absorption
Active Site ACT_SITE 74; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 121; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 216; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.; EC=3.4.21.2;
DNA Binding
EC Number 3.4.21.2
Enzyme Function FUNCTION: Has chymotrypsin-type protease activity and hypocalcemic activity. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (5); Domain (1); Glycosylation (4); Propeptide (1); Signal peptide (1)
Keywords Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Serine protease;Signal;Zymogen
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..16; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 12466851; 21471529; 23814066; 25063451; 31211695; 31973822;
Motif
Gene Encoded By
Mass 29,470
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda