Detail Information for IndEnz0002018888
IED ID IndEnz0002018888
Enzyme Type ID protease018888
Protein Name DNA damage-inducible protein 1
EC 3.4.23.-
Gene Name DDI1 YALI0B06754g
Organism Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Dipodascaceae Yarrowia Yarrowia lipolytica (Candida lipolytica) Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Enzyme Sequence MQIFVTTPSENVFGLEVAADMAYEDLLAFVEMEASVPSKDIILSLNGNPIVDTDPKATIGSLGVTDNSMLLLTTKRVAPNPSTSAQPAIPTLDFSSIQIPGLPAAQRVDPRAEQIRTQILERADSLDQLKLSNPELAEHVHDSQKFSDAFTKLQNELRAKEVERKKELQRLYADPDNEDNQKRIMEIIRQENVEESYQNAMEHHPEMFIRTDMLYINCRINGHDVKAFVDTGAQMTILSEEFCEKVGLSHMLDVKFAGVARGVGSGKILGRVHSVPLQIGSSFFPASVSVIEGDQLQFILGLDMLKRFKANVNLRTNQLEIGEEKATFLGEKDLPDEFGKLGQEKEKKQDHGSAGDAFKDEDIVNLMSLGYSREKVVVALKQTDGDVELAASLLFSQ
Enzyme Length 397
Uniprot Accession Number Q6CFI3
Absorption
Active Site ACT_SITE 230; /evidence=ECO:0000305
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.23.-
Enzyme Function FUNCTION: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. {ECO:0000250|UniProtKB:I7HUG0, ECO:0000250|UniProtKB:P40087}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Domain (2)
Keywords Aspartyl protease;Cytoplasm;Hydrolase;Protease;Protein transport;Reference proteome;Transport
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 44,034
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda