Detail Information for IndEnz0002018891
IED ID IndEnz0002018891
Enzyme Type ID protease018891
Protein Name Cysteine proteinase 2
EC 3.4.22.-
Amastigote cysteine proteinase A-2
Gene Name CYS2
Organism Leishmania pifanoi
Taxonomic Lineage cellular organisms Eukaryota Discoba Euglenozoa Kinetoplastea (kinetoplasts) Metakinetoplastina Trypanosomatida Trypanosomatidae Leishmaniinae Leishmania Leishmania Leishmania mexicana species complex Leishmania pifanoi
Enzyme Sequence MATSRAALCAVAVVCVVLAAACAPARAIHVGTPAAALFEEFKRTYGRAYETLAEEQQRLANFERNLELMREHQARNPHAQFGITKFFDLSEAEFAARYLNGAAYFAAAKRHAAQHYRKARADLSAVPDAVDWREKGAVTPVKDQGACGSCWAFSAVGNIEGQWYLAGHELVSLSEQQLVSCDDMNDGCDGGLMLQAFDWLLQNTNGHLHTEDSYPYVSGNGYVPECSNSSEELVVGAQIDGHVLIGSSEKAMAAWLAKNGPIAIALDASSFMSYKSGVLTACIGKQLNHGVLLVGYDMTGEVPYWVIKNSWGGDWGEQGYVRVVMGVNACLLSEYPVSAHVRESAAPGTSTSSETPAPRPVMVEQVICFDKNCTQGCRKTLIKANECHKNGGGGASMIKCSPQKVTMCTYSNEFCVGGGLCFETPDGKCAPYFLGSIMNTCHYT
Enzyme Length 444
Uniprot Accession Number Q05094
Absorption
Active Site ACT_SITE 150; /evidence=ECO:0000250; ACT_SITE 289; /evidence=ECO:0000250; ACT_SITE 309; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.22.-
Enzyme Function FUNCTION: The cysteine proteinases have a potential role in host-parasite interaction and virulence.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (1); Glycosylation (2); Propeptide (1); Signal peptide (1)
Keywords Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Signal;Thiol protease;Virulence;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Lysosome. Note=Associated with megasome, a unique lysosomal organelle found in intracellular amastigotes of the L.mexicana complex.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /note=Or 27
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 47,857
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda