| IED ID | IndEnz0002018896 |
| Enzyme Type ID | protease018896 |
| Protein Name |
Ferritin BfrB EC 1.16.3.1 Bacterioferritin Non-heme ferritin Ftn Nox19 |
| Gene Name | bfrB ERDMAN_4208 |
| Organism | Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Corynebacteriales Mycobacteriaceae Mycobacterium Mycobacterium tuberculosis complex Mycobacterium tuberculosis Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) |
| Enzyme Sequence | MTEYEGPKTKFHALMQEQIHNEFTAAQQYVAIAVYFDSEDLPQLAKHFYSQAVEERNHAMMLVQHLLDRDLRVEIPGVDTVRNQFDRPREALALALDQERTVTDQVGRLTAVARDEGDFLGEQFMQWFLQEQIEEVALMATLVRVADRAGANLFELENFVAREVDVAPAASGAPHAAGGRL |
| Enzyme Length | 181 |
| Uniprot Accession Number | H8F1Z2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O; Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1; |
| DNA Binding | |
| EC Number | 1.16.3.1 |
| Enzyme Function | FUNCTION: Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Erroneous initiation (1); Metal binding (6) |
| Keywords | Iron;Iron storage;Metal-binding;Oxidoreductase |
| Interact With | |
| Induction | INDUCTION: Repressed by Rip1, highly induced by metal chelator phenanthroline in the absence of Rip1. {ECO:0000269|PubMed:20545848}. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 20,442 |
| Kinetics | |
| Metal Binding | METAL 22; /note=Iron 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 55; /note=Iron 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 55; /note=Iron 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 58; /note=Iron 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 99; /note=Iron 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 132; /note=Iron 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085 |
| Rhea ID | RHEA:11148 |
| Cross Reference Brenda |