Detail Information for IndEnz0002018896
IED ID IndEnz0002018896
Enzyme Type ID protease018896
Protein Name Ferritin BfrB
EC 1.16.3.1
Bacterioferritin
Non-heme ferritin Ftn
Nox19
Gene Name bfrB ERDMAN_4208
Organism Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Corynebacteriales Mycobacteriaceae Mycobacterium Mycobacterium tuberculosis complex Mycobacterium tuberculosis Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Enzyme Sequence MTEYEGPKTKFHALMQEQIHNEFTAAQQYVAIAVYFDSEDLPQLAKHFYSQAVEERNHAMMLVQHLLDRDLRVEIPGVDTVRNQFDRPREALALALDQERTVTDQVGRLTAVARDEGDFLGEQFMQWFLQEQIEEVALMATLVRVADRAGANLFELENFVAREVDVAPAASGAPHAAGGRL
Enzyme Length 181
Uniprot Accession Number H8F1Z2
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O; Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1;
DNA Binding
EC Number 1.16.3.1
Enzyme Function FUNCTION: Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Domain (1); Erroneous initiation (1); Metal binding (6)
Keywords Iron;Iron storage;Metal-binding;Oxidoreductase
Interact With
Induction INDUCTION: Repressed by Rip1, highly induced by metal chelator phenanthroline in the absence of Rip1. {ECO:0000269|PubMed:20545848}.
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 20,442
Kinetics
Metal Binding METAL 22; /note=Iron 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 55; /note=Iron 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 55; /note=Iron 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 58; /note=Iron 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 99; /note=Iron 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085; METAL 132; /note=Iron 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00085
Rhea ID RHEA:11148
Cross Reference Brenda