| IED ID | IndEnz0002018898 |
| Enzyme Type ID | protease018898 |
| Protein Name |
Zinc carboxypeptidase A 1 EC 3.4.17.- AgCP |
| Gene Name | AGAP009593 |
| Organism | Anopheles gambiae (African malaria mosquito) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Nematocera Culicomorpha Culicoidea Culicidae (mosquitos) Anophelinae Anopheles Cellia Pyretophorus gambiae species complex Anopheles gambiae (African malaria mosquito) |
| Enzyme Sequence | MVRLNSAAGSRWWAPAMAILAVALSVEAAEVARYDNYRLYRVTPHSEAQLRSVAAMEQASDSLIFLETARKLGDRFDIVVAPHKLADFTETLESDYIPHELIEQNVQRAFDEERVRLTNKRAKGPFDWNDYHTLEEIHAWLDQLASEHPKEVELLDAGRSHQNRTMKGVKLSYGPGRPGVFLEGGIHAREWISPATVTYILNQLLTSEDAKVRALAEKFDWYVFPNANPDGYAYTFQVNRLWRKTRKAYGPFCYGADPNRNWDFHWAEQGTSNNACSDTYHGSEAFSEVETRSLAAFVEKLRGKLGAYIAFHSYSQLLLFPYGHTGEHSPNHQDLNEIAEATVKSLAKRYGTQYKYGNVYDAIYPASGSSVDWSYGAQDVKIAYTYELRPDGDAWNGFVLPPNEIVPTGEETLDSLITLLEESSARGYYDEKH |
| Enzyme Length | 433 |
| Uniprot Accession Number | O02350 |
| Absorption | |
| Active Site | ACT_SITE 387; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:P00730 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.17.- |
| Enzyme Function | FUNCTION: Involved in the digestion of the blood meal. {ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (1); Metal binding (3); Sequence conflict (4); Signal peptide (1) |
| Keywords | Carboxypeptidase;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Zinc |
| Interact With | |
| Induction | INDUCTION: By blood meal, 10 fold increase within 10 hours. {ECO:0000269|PubMed:9569647}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9569647}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..28; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 49,099 |
| Kinetics | |
| Metal Binding | METAL 187; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 190; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 312; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730 |
| Rhea ID | |
| Cross Reference Brenda |