Detail Information for IndEnz0002018901
IED ID IndEnz0002018901
Enzyme Type ID protease018901
Protein Name Mast cell carboxypeptidase A
MC-CPA
EC 3.4.17.1
Carboxypeptidase A3
Gene Name CPA3
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MRLILPVGLIATTLAIAPVRFDREKVFRVKPQDEKQADIIKDLAKTNELDFWYPGATHHVAANMMVDFRVSEKESQAIQSALDQNKMHYEILIHDLQEEIEKQFDVKEDIPGRHSYAKYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIGEKNERRKAIFTDCGIHAREWVSPAFCQWFVYQATKTYGRNKIMTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRSKNQNSKCIGTDLNRNFNASWNSIPNTNDPCADNYRGSAPESEKETKAVTNFIRSHLNEIKVYITFHSYSQMLLFPYGYTSKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISGSSLDWAYDLGIKHTFAFELRDKGKFGFLLPESRIKPTCRETMLAVKFIAKYILKHTS
Enzyme Length 417
Uniprot Accession Number P15088
Absorption
Active Site ACT_SITE 378; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:P00730
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.; EC=3.4.17.1;
DNA Binding
EC Number 3.4.17.1
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (2); Metal binding (3); Natural variant (2); Propeptide (1); Sequence conflict (4); Signal peptide (1)
Keywords Carboxypeptidase;Cytoplasmic vesicle;Direct protein sequencing;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..15
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 14760754; 19643669; 2443571; 24726923; 27157394; 29512095; 34057753;
Motif
Gene Encoded By
Mass 48,670
Kinetics
Metal Binding METAL 176; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 179; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 304; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730
Rhea ID
Cross Reference Brenda 3.4.17.1;