Detail Information for IndEnz0002018902
IED ID IndEnz0002018902
Enzyme Type ID protease018902
Protein Name Mast cell carboxypeptidase A
MC-CPA
EC 3.4.17.1
Carboxypeptidase A3
Gene Name Cpa3
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MRFFLLMAVIYTTLAIAPVHFDREKVFRVKLQNEKHASVLKNLTQSIELDFWYPDAIHDIAVNMTVDFRVSEKESQTIQSTLEQHKIHYEILIHDLQEEIEKQFDVKDEIAGRHSYAKYNDWDKIVSWTEKMLEKHPEMVSRIKIGSTVEDNPLYVLKIGKKDGERKAIFMDCGIHAREWISPAFCQWFVYQATKSYGKNKIMTKLLDRMNFYVLPVFNVDGYIWSWTQDRMWRKNRSRNQNSTCIGTDLNRNFDVSWDSSPNTNKPCLNVYRGPAPESEKETKAVTNFIRSHLNSIKAYITFHSYSQMLLIPYGYTFKLPPNHQDLLKVARIATDALSTRYETRYIYGPIASTIYKTSGSSLDWVYDLGIKHTFAFELRDKGKSGFLLPESRIKPTCKETMLSVKFIAKYILKNTS
Enzyme Length 417
Uniprot Accession Number P15089
Absorption
Active Site ACT_SITE 378; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:P00730
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.; EC=3.4.17.1;
DNA Binding
EC Number 3.4.17.1
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (2); Metal binding (3); Propeptide (1); Signal peptide (1)
Keywords Carboxypeptidase;Cytoplasmic vesicle;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..15
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10466726; 11707070; 12466851; 15173164; 15226823; 15860733; 15988029; 1744088; 17923505; 19110448; 20530543; 21076070; 21267068; 21677750; 21926462; 22001390; 22101159; 23624557; 23636054; 23975861; 24194600; 24227781; 24257755; 24416383; 24917576; 25326799; 25843682; 25879437; 25915587; 2594780; 25955205; 26449668; 27021404; 27353089; 28193842; 28350850; 28375155; 28869965; 28990934; 29463838; 30013146; 30318340; 30571485; 31931959; 33097573; 33442055; 7515715; 8018917; 8098710; 8562971;
Motif
Gene Encoded By
Mass 48,790
Kinetics
Metal Binding METAL 176; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 179; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 304; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730
Rhea ID
Cross Reference Brenda