Detail Information for IndEnz0002018910
IED ID IndEnz0002018910
Enzyme Type ID protease018910
Protein Name Probable dipeptidyl-aminopeptidase B
DPAP B
EC 3.4.14.5
Gene Name DAPB PABG_03771
Organism Paracoccidioides brasiliensis (strain Pb03)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Onygenales incertae sedis Paracoccidioides Paracoccidioides brasiliensis Paracoccidioides brasiliensis (strain Pb03)
Enzyme Sequence MAAEKGGSSDEERKPLTRGGMEYRDSSNSLHYSSSAASLSLAVIDRINGSTHDTGPDEIGRGDRDYSDDGEYDIEEADYIPSGGKPVQKKVKIVLGFLLFLCLSGWSLAFVLFLFGGHESSKTSIVYEDNISDTGSQGIKITLDEVFDGTWSPNSRDISWIPGPNGEDGLLLEKGASISNGYLRVEDIVSRKDPKSSKKPIVLMQKAYFNVSGEAVFPSRVWPSPDLKTVLVLSNEEKNWRHSFTGKYWLFDVESQTGQPLDPAAKDQRVQLASWSPRSDAVVFTRDNNMFLRKLSSNEVIKITTNGGVNLFYGVPDWVYEEEVFSGNSVTWWADDGEYIAFLRTNESSVPEYPVQYFVSRPNGEIPKPGGESYPETRKIKYPKAGAPNPIVDLQFFDVGKDEVFSVDIKGDFADSNRLIIEVVWASNGKVIVRSTNRESDVLHVAVIDVFSRTGKIVRKEDINALDGGWVEPSQTTRFIPADPDNGRLNDGYIDTVIYEGRDQLAYYTPIDNPKPIVLTNGHSEVVQAPSGVDLKRGLVYFVVAGNEPWERHIYSVNFDGTSLQPVTNVSESSYYDVSFSNGAGYAFLKYAGPQVPWQKVISTPANEVTFEETIEENNHLSERLRQYTLESKIYQYIDIDGFSLPVLERRPPNFNQTKKYPVLFYLYGGPGSQTVKKKFNVDFQSYVAANLGYIVVTVDGRGTGFIGRKARCIIRGNLGHFESRDQIQAAKIWAAKPYVDESRISIWGWSYGGFMALKTIEQDGGRTFKYGIAVAPVTDWRYYDSIYTERYMHTPQRNPGGYDNAAISNTTALANNIRFLVMHGTADDNVHIQNSLTFIDKLDVNNVHNYDVHFFPDSDHSIYFHNAHKIVYSRLADWLVNAFNGEWLKTYDPTPNDSILRRAATWVGMSI
Enzyme Length 912
Uniprot Accession Number C0S7H1
Absorption
Active Site ACT_SITE 751; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10084; ACT_SITE 828; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10084; ACT_SITE 861; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10084
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; Evidence={ECO:0000255|PROSITE-ProRule:PRU10084};
DNA Binding
EC Number 3.4.14.5
Enzyme Function FUNCTION: Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Compositional bias (1); Glycosylation (7); Region (2); Topological domain (2); Transmembrane (1)
Keywords Aminopeptidase;Glycoprotein;Hydrolase;Membrane;Protease;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix;Vacuole
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Lysosome-like vacuoles. {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 102,355
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda