| IED ID | IndEnz0002018935 |
| Enzyme Type ID | protease018935 |
| Protein Name |
Cathepsin E-A EC 3.4.23.34 |
| Gene Name | ctse-a ce1 |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MRQILVLLLFATLVYGLIRVPLKRQKSIRKTLKEKGKLSHIWTQQGIDMVQYTDSCSNDQAPSEPLINYMDVEYFGEISVGTPPQNFTVIFDTGSSNLWVPSVYCISQACAQHDRFQPQLSSTYESNGNNFSLQYGTGSLSGVIGIDAVTVEGILVQNQQFGESVSEPGSTFVDAEFDGILGLGYPSIAVGDCTPVFDNMIAQNLVELPMFSVYMSRNPNSAVGGELVFGGFDASRFSGQLNWVPVTNQGYWQIQLDNVQINGEVLFCSGGCQAIVDTGTSLITGPSSDIVQLQNIIGASAANGDYEVDCSVLNEMPTVTFTINGIGYQMTPQQYTLQDGGGVCSSGFQGLDIPPPAGPLWILGDVFIGQYYSVFDRGNNRVGLAPVVPYPPLKNGV |
| Enzyme Length | 397 |
| Uniprot Accession Number | Q805F3 |
| Absorption | |
| Active Site | ACT_SITE 92; /evidence="ECO:0000250|UniProtKB:P00790, ECO:0000255|PROSITE-ProRule:PRU10094"; ACT_SITE 277; /evidence="ECO:0000250|UniProtKB:P00790, ECO:0000255|PROSITE-ProRule:PRU10094" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Similar to cathepsin D, but slightly broader specificity.; EC=3.4.23.34; Evidence={ECO:0000269|PubMed:14561724}; |
| DNA Binding | |
| EC Number | 3.4.23.34 |
| Enzyme Function | FUNCTION: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation (By similarity). {ECO:0000250|UniProtKB:P14091}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (3); Domain (1); Glycosylation (2); Propeptide (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Direct protein sequencing;Disulfide bond;Endosome;Glycoprotein;Hydrolase;Protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endosome {ECO:0000250}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: Glycosylated. Contains high mannose-type oligosaccharide. {ECO:0000269|PubMed:14561724}. |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000269|PubMed:14561724 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,907 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |