Detail Information for IndEnz0002018951
IED ID IndEnz0002018951
Enzyme Type ID protease018951
Protein Name Carboxypeptidase N catalytic chain
CPN
EC 3.4.17.3
Carboxypeptidase N polypeptide 1
Carboxypeptidase N small subunit
Gene Name CPN1
Organism Bos taurus (Bovine)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine)
Enzyme Sequence MSDLVSIFLHLLLFKLVAPVTFRHHRYDDLVRMLYKVHNECPHITRVYSIGRSVKGRHLYVLEFSDYPGIHEPLEPEVKYVGNMHGNEVLGRELLLQLSEFLCEEFRNRNQRIVRLVEDTRIHIMPSMNPDGYEVAAAAQERDISGYLVGRNNANGVDLNRNFPDLNTYIYYNEKNGGPNHHFPLPDNWKSQVEPETQAVIQWIRSFNFVLSANLHGGAVVANYPYDKSLGHRVRGFRRTANTPTPDDKLFQKLAKIYSYAHGWMHQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPLQGELQREWLGNREALIQFLEQVHQGIKGMVRDENYNNLADAVISVGGINHDVTSGAHGDYFRLLLPGTYTVTATAPGFDPETVSVTVGPAEPKLVNFQLKRSTPQAAPKRRIPNSGHRGRVLPKKVQPRAARKKETMMKQPQRGPA
Enzyme Length 462
Uniprot Accession Number Q2KJ83
Absorption
Active Site ACT_SITE 308; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:P14384
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of a C-terminal basic amino acid, preferentially lysine.; EC=3.4.17.3;
DNA Binding
EC Number 3.4.17.3
Enzyme Function FUNCTION: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Compositional bias (1); Disulfide bond (2); Glycosylation (1); Metal binding (3); Region (2); Signal peptide (1)
Keywords Carboxypeptidase;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000250
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 52,669
Kinetics
Metal Binding METAL 85; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 88; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 216; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730
Rhea ID
Cross Reference Brenda