| IED ID | IndEnz0002018962 |
| Enzyme Type ID | protease018962 |
| Protein Name |
Carboxypeptidase Y homolog A EC 3.4.16.5 |
| Gene Name | cpyA PMAA_064090 |
| Organism | Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Trichocomaceae Talaromyces Talaromyces sect. Talaromyces Talaromyces marneffei (Penicillium marneffei) Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei) |
| Enzyme Sequence | MRGLATTLLIGAAAAATYPAQQVLKAPEEVLEKTHKTSSSSLAETLARPLHELNEELKSLTAEAEEVWEQVSNMFPGALDNIPFFSSPKKHTRRPDSHWDHIVRGADVQNIWVENENGEKEREVGGRLETFDLRVKAVDPSSLGIDPDVKQYSGYLDDNENDKHLFYWFFESRNDPKNDPVVLWLNGGPGCSSLTGLFFELGPSSIGKNIKPIYNPYSWNSNASVIFLDQPVNVGFSYSGNSVSETSAAAKDVYALLTLFFKQFPEYATQDFHIAGESYAGHYIPSFASEILSHKKRNINLKSVLIGNGLTDGFTQYEYYRPMACGDGGYPAVLDESACRSMDNALGRCQSMIQSCYDSESAWTCVPASIYCNNALLGPYQRTGQNVYDIRKPCEGSSLCYADLEYISTYLNQAEVLKAVGAEVDSFDSCNFDINRNFLFKGDWMKPFHKLVPGILEEIPVLIYAGDADFICNWLGNKAWSDALEWSGHEEYAATELEDLEIVDNEHKGKKIGQVKSSGNLTFMRLFGGGHMVPYDQPEASLEFFNRWIGGEWTK |
| Enzyme Length | 555 |
| Uniprot Accession Number | B6QAN5 |
| Absorption | |
| Active Site | ACT_SITE 278; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 469; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 531; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of a C-terminal amino acid with broad specificity.; EC=3.4.16.5; Evidence={ECO:0000255|PROSITE-ProRule:PRU10074}; |
| DNA Binding | |
| EC Number | 3.4.16.5 |
| Enzyme Function | FUNCTION: Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (5); Glycosylation (2); Propeptide (1); Signal peptide (1) |
| Keywords | Carboxypeptidase;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Signal;Vacuole;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 61,987 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |