Detail Information for IndEnz0002018968
IED ID IndEnz0002018968
Enzyme Type ID protease018968
Protein Name Viral cathepsin
V-cath
EC 3.4.22.50
Cysteine proteinase
CP
Gene Name VCATH 16
Organism Spodoptera exigua nuclear polyhedrosis virus (strain US) (SeMNPV)
Taxonomic Lineage Viruses Naldaviricetes Lefavirales Baculoviridae Alphabaculovirus Spodoptera exigua multiple nucleopolyhedrovirus Spodoptera exigua nuclear polyhedrosis virus (strain US) (SeMNPV)
Enzyme Sequence MNKLLILFLLLNAALTRQDNHASANNKPMLYNINSAPLYFEKFITQYNKQYKSEDEKKYRYNIFRHNIESINQKNSRNDSAVYKINRFADMPKNEIVIRHTGLASGELGLNFCETIVVDGPAQRQRPVSFDWRSMNKITSVKDQGMCGACWRFASLGALESQYAIKYDRLIDLSEQQLVDCDFVDMGCDGGLIHTAYEQIMKMGGVEQEFDYSYKAERQPCALKPHKFATGVRNCYRYVILNEERLEDLLRYVGPIAIAVDAVDLTDYYGGIVSFCENNGLNHAVLLVGYGVENNVPYWIIKNSWGSDYGEDGYVRVRRGVNSCGMINELASSAQVV
Enzyme Length 337
Uniprot Accession Number Q9J8B9
Absorption
Active Site ACT_SITE 150; /evidence=ECO:0000250; ACT_SITE 283; /evidence=ECO:0000250; ACT_SITE 303; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.; EC=3.4.22.50;
DNA Binding
EC Number 3.4.22.50
Enzyme Function FUNCTION: Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (3); Propeptide (1); Signal peptide (1)
Keywords Disulfide bond;Hydrolase;Protease;Signal;Thiol protease;Zymogen
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification PTM: Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide. {ECO:0000250}.
Signal Peptide SIGNAL 1..16; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 38,387
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda