Detail Information for IndEnz0002018976
IED ID IndEnz0002018976
Enzyme Type ID protease018976
Protein Name D-aminopeptidase
EC 3.4.11.19
Gene Name dap BOV_A0889
Organism Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Alphaproteobacteria Hyphomicrobiales Brucellaceae Brucella/Ochrobactrum group Brucella Brucella ovis Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Enzyme Sequence MPNIDLPTLEAFVHAIPQNYKGPGGAVAVVRNGEIVLRHAWGFADLAARKAMTPETRMPICSVSKQFTCAVLLDCIGEPEMLDSALAAYLDQFGDGRPAVRDLCNNQSGLRDYWALTVLCGAAPEGIFLPDQAQNLLRRLKTTHFAPGTHYSYCNGNFRILADLIEQHTGRSLADLLAERIFAPAAMKTAELIPDTALFNECTGYEGDTVHGFLPAINRIHWLGDAGICASLDDMIAWEQFIDRTRHDENGLYRRLSSPQTFADGAPAPYGFGLKFEETGGKRLTGHGGALRGWRCQRWHCADERISTIVMFNFEGNASDAALKMMNAALGIPPAKPVRAQANPGWFGSWLNPETGLVLSLEDAGGGRMKARFGTGPEIMDISGENEAQSSMTTLRRDGDMIHLARKDENLHLAMHRLKGEARQDIAGRYRSDELEADLLLVSEGGAIYGAFEGFLGKSDMYPLYAAGPDVWLLPVQRSMDAPSPGEWKLVFHRDAAGRITGVTVGCWLARGVEYKRL
Enzyme Length 518
Uniprot Accession Number A5VVL2
Absorption
Active Site ACT_SITE 62; /note=Nucleophile; /evidence=ECO:0000255|HAMAP-Rule:MF_01960; ACT_SITE 65; /note=Proton donor/acceptor; /evidence=ECO:0000255|HAMAP-Rule:MF_01960
Activity Regulation ACTIVITY REGULATION: Inhibited by beta-lactam compounds such as 6-aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate. {ECO:0000255|HAMAP-Rule:MF_01960}.
Binding Site BINDING 481; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_01960
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of an N-terminal D-amino acid from a peptide, Xaa-|-Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-amino acid amides and methyl esters also are hydrolyzed, as is glycine amide.; EC=3.4.11.19; Evidence={ECO:0000255|HAMAP-Rule:MF_01960};
DNA Binding
EC Number 3.4.11.19
Enzyme Function FUNCTION: Hydrolyzes N-terminal residues in D-amino acid-containing peptides. {ECO:0000255|HAMAP-Rule:MF_01960}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Binding site (1); Chain (1); Region (1)
Keywords Aminopeptidase;Hydrolase;Protease
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 56,782
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda