| IED ID | IndEnz0002018983 |
| Enzyme Type ID | protease018983 |
| Protein Name |
Chondroadherin 38 kDa bone protein Cartilage leucine-rich protein Cleaved into: Chondroadherin minor form |
| Gene Name | CHAD |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MARPMLLLXLSLGLLASLLPALAACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLATNSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRSGAFQGAKDLRWLYLSENSLSSLQPGALDDVENLAKFYLDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLHQLPSNFPFDSLETLTLTNNPWKCTCQLRGLRRWLEAKTSRPDATCASPAKFRGQHIRDTDAFRGCKFPTKRSKKAGRH |
| Enzyme Length | 361 |
| Uniprot Accession Number | Q27972 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (2); Disulfide bond (3); Domain (2); Glycosylation (1); Repeat (9); Sequence conflict (5); Signal peptide (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Extracellular matrix;Glycoprotein;Leucine-rich repeat;Reference proteome;Repeat;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..24; /note=Or 23; in some isoform(s); /evidence=ECO:0000269|PubMed:7814406 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 22038862; |
| Motif | |
| Gene Encoded By | |
| Mass | 40,885 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |