Detail Information for IndEnz0002018984
IED ID IndEnz0002018984
Enzyme Type ID protease018984
Protein Name Death domain-containing protein CRADD
Caspase and RIP adapter with death domain
RIP-associated protein with a death domain
Gene Name Cradd Raidd
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEIKAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLEKAREEVTAELPTGDWMAGIPSHILSSSPSDQQINQLAQRLGPEWEPVVLSLGLSQTDIYRCKANHPHNVHSQVVEAFVRWRQRFGKQATFLSLHKGLQAVEADPSLLQHMLE
Enzyme Length 199
Uniprot Accession Number O88843
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. {ECO:0000250|UniProtKB:P78560}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Domain (2); Mutagenesis (1); Sequence conflict (1)
Keywords Apoptosis;Cytoplasm;Nucleus;Reference proteome
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22279524}. Nucleus {ECO:0000269|PubMed:22279524}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10442092; 12459263; 12466851; 12520002; 12558660; 12819136; 12904583; 14610273; 15741512; 15865046; 16141072; 16183742; 16362053; 16602821; 17062627; 17967808; 18799693; 19364921; 21731673; 22323537; 22515271; 23815625; 24958727; 25857265; 27773430;
Motif
Gene Encoded By
Mass 22,656
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda