IED ID | IndEnz0002018990 |
Enzyme Type ID | protease018990 |
Protein Name |
Probable dipeptidyl-aminopeptidase B DPAP B EC 3.4.14.5 |
Gene Name | DAPB NECHADRAFT_47100 |
Organism | Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) (Fusarium solani subsp. pisi) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Hypocreomycetidae Hypocreales Nectriaceae Fusarium Fusarium solani species complex Fusarium vanettenii (Neocosmospora pisi) Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) (Fusarium solani subsp. pisi) |
Enzyme Sequence | MSSALSPEGDRRYSDDSLSSVSTTSLVFERIQEKTEMDADNDKEKDPRALDDEDPLRDEDDLETGPFLGPGASLHREPMDRGLRRILIIVAVVFIGGWLAGLGIFIASGSYHHESDTEHDPDANSRGSGKSLSMDQLFDGTWSPKYHSISWIAGPKGEDGLLLEVGASNKPYIVVEDIRSDKNVATRDDAEPKASNSRTLMEHPYFEYDGKQYSPSWSEPSPDLTKVLLGVDRKKNWRHSFSAIYFVLDVKTQEAEPLVPDQVDARIQLASWSPKSDAVSFTRENNLYIRRLTGDKDVTQITKDGGPEYFYGIPDWVYEEEVFSGRSATWWSDDGKYLAFLRTNETGVPEYPVQFFIERPSGTTPEDGEEAYPEVEQIKYPKAGAHNPVVDLQFYDIGKKDTFSVEIDGAFADDDRIINNLLWAGDKAIVKQTNRVSDVLKVVLVDVPSRKGKTINTININEIDGGWFEISHKMTYIPADPKNGREHDGYVDSVIHEGYDHLAYFTPLDNSEPIMLTKGNWEVDDAPSAVDLANNLVYFIAAKESSIQRHVYSVKLDGSDLQALTDPKTEAYYDASFSKGAGFVFLSYRGPKVPTQKVISTPVSASSYERIIEDNAELADRARRHELPILKYGTLDLDTGVKVNYVERRPPHFDAKKQYPVLFHQYSGPGSQSVTKRFAVDFQAYVAAALGYLVITVDPRGTGFLGRKHRVTVRSKLGVHEAHDHIAAAASFASRPYVDAERLAIWGWSYGGFTTLKTLEQDAGRTFSYGMAVAPVTDWRFYDSIYTERYMRTPQDNPDGYDLSKVANATALGENKRFLLMHGVADDNVHFQNSLTLLDDLDLAGVENYDVHVFPDSDHSIYFHNGNRIVYDKLRNWLINAFNGEWLKVSNPQPQKDPVEKEKRHMVPQALV |
Enzyme Length | 912 |
Uniprot Accession Number | C7YYG9 |
Absorption | |
Active Site | ACT_SITE 749; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 826; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 859; /note=Charge relay system; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; |
DNA Binding | |
EC Number | 3.4.14.5 |
Enzyme Function | FUNCTION: Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Chain (1); Compositional bias (3); Glycosylation (2); Region (2); Topological domain (2); Transmembrane (1) |
Keywords | Aminopeptidase;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix;Vacuole |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Lysosome-like vacuoles. {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 102,536 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |