| IED ID | IndEnz0002019000 |
| Enzyme Type ID | protease019000 |
| Protein Name |
Cystatin Fragment |
| Gene Name | |
| Organism | Naja atra (Chinese cobra) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Elapidae Elapinae Naja Naja atra (Chinese cobra) |
| Enzyme Sequence | IPGGLSPRSVSDPDVQKAAAFAVQEYNAGSANAHYYKELRVVEAQSQSVAGEKYFLMMELVKTKCAKTAGKPKVYKEIQNCELPPIKQQEEKLCGFQVW |
| Enzyme Length | 99 |
| Uniprot Accession Number | P81714 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits various C1 cysteine proteases including cathepsin L (Ki is 0.1 nM), papain (Ki is 0.19 nM), cathepsin S (Ki is 1.2 nM), and cathepsin B (Ki is 2.5 nM). This protein has no toxic activity and its function in the venom is unknown. It may play a role as housekeeping or regulatory protein. {ECO:0000269|PubMed:9512485}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Domain (1); Motif (1); Non-terminal residue (1); Site (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Protease inhibitor;Secreted;Thiol protease inhibitor |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 47..51; /note=Secondary area of contact; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 10,995 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |