Detail Information for IndEnz0002019002
IED ID IndEnz0002019002
Enzyme Type ID protease019002
Protein Name Desumoylating isopeptidase 1
DeSI-1
EC 3.4.-.-
PPPDE peptidase domain-containing protein 2
Polyubiquitinated substrate transporter
POST
Gene Name DESI1 FAM152B PPPDE2
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSGGISSCPPGGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPLLDSIQIQPPGGSSVGRPNGQS
Enzyme Length 168
Uniprot Accession Number Q6ICB0
Absorption
Active Site ACT_SITE 38; /evidence=ECO:0000255|PROSITE-ProRule:PRU01205; ACT_SITE 108; /evidence=ECO:0000255|PROSITE-ProRule:PRU01205
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.-.-
Enzyme Function FUNCTION: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). {ECO:0000250|UniProtKB:Q9CQT7, ECO:0000269|PubMed:29666234}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Beta strand (5); Chain (1); Domain (1); Helix (7); Motif (2); Turn (4)
Keywords 3D-structure;Cytoplasm;Hydrolase;Nucleus;Protease;Reference proteome
Interact With Q9P2A4; Q8TD06; Q9H305; P78358; O75638-2; Q15038; P30040; P34910-2; Q8NBJ4; Q4KN05; Q6FHY5; Q13232; Q9H0P0; P85299-2; P78317; P62979; Q96DD7; Q8N114-3; Q3B7S5; P59536; P62987; P0CG47; P0CG48; Q9UMX0; Q9UHD9; Q8IYU4; Q96PU4-2; A0A1U9X8X8
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29666234}. Nucleus {ECO:0000269|PubMed:29666234}. Note=Shuttles between the nucleus and the cytoplasm; exported from the nucleus in a XPO1/CRM1-dependent manner via its nuclear export signal motifs. {ECO:0000269|PubMed:29666234}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (1)
Cross Reference PDB 3EBQ;
Mapped Pubmed ID 19913121; 20628086; 20711500; 21988832; 26496610;
Motif MOTIF 83..91; /note=Nuclear export signal 1; /evidence=ECO:0000269|PubMed:29666234; MOTIF 139..153; /note=Nuclear export signal 2; /evidence=ECO:0000269|PubMed:29666234
Gene Encoded By
Mass 18,263
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda