Detail Information for IndEnz0002019003
IED ID IndEnz0002019003
Enzyme Type ID protease019003
Protein Name Desumoylating isopeptidase 1
DeSI-1
EC 3.4.-.-
PPPDE peptidase domain-containing protein 2
Gene Name desi1 fam152b pppde2
Organism Xenopus laevis (African clawed frog)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog)
Enzyme Sequence METAEGPHLVRLYVYDMSRGLARRLSPVMLGKQLEGIWHTSIIVFDEEFFYGREGITSCLPGRTMLGEPDSVMELGITEVTEEIFLEYLSSLGESGFSGESYHLFDHNCNTFSNEVAQFLTGKKIPSYITELPSEVLSTPLGQALRPLLDSVQIQPAGGNIFNRQSGPS
Enzyme Length 169
Uniprot Accession Number Q6GLM5
Absorption
Active Site ACT_SITE 39; /evidence=ECO:0000255|PROSITE-ProRule:PRU01205; ACT_SITE 109; /evidence=ECO:0000255|PROSITE-ProRule:PRU01205
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.-.-
Enzyme Function FUNCTION: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins (By similarity). Has isopeptidase but not SUMO-processing activity (By similarity). Collaborates with ubqln4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q6ICB0, ECO:0000250|UniProtKB:Q9CQT7}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Domain (1); Motif (2)
Keywords Cytoplasm;Hydrolase;Nucleus;Protease
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9CQT7}. Nucleus {ECO:0000250|UniProtKB:Q9CQT7}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif MOTIF 84..92; /note=Nuclear export signal 1; /evidence=ECO:0000250|UniProtKB:Q6ICB0; MOTIF 140..154; /note=Nuclear export signal 2; /evidence=ECO:0000250|UniProtKB:Q6ICB0
Gene Encoded By
Mass 18,737
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda